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Fig. 3 | BMC Cancer

Fig. 3

From: Minocycline prevents and repairs the skin disorder associated with afatinib, one of the epidermal growth factor receptor-tyrosine kinase inhibitors for non-small cell lung cancer

Fig. 3

Effect of minocycline WP on the TEWL value after afatinib oral administration. a Upper half is the TEWL value of the neck of the mice for 18 days. Lower half is the TEWL value of the buttocks of mice pretreated with minocycline WP (orange square) from 3 days before afatinib administration compared with WP (blue circle) as control. b Effects of treatment by WP or minocycline WP after onset of the rash. Upper is neck, and lower is treatment with minocycline WP from 7 days after start of administration. Data (mean ± SD, n = 4 per group are compared by one-way analysis of variance. *P < 0.05, **P < 0.01 versus control

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