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Table 4 Cox proportional hazards regression model for overall survival in hypopharyngeal and laryngeal squamous cell carcinoma

From: Prognostic implications of Fibroblast growth factor receptor 1 (FGFR1) gene amplification and protein overexpression in hypopharyngeal and laryngeal squamous cell carcinoma

VariablesUnivariateMultivariate
P valueHR (95% CI)P valueHR (95% CI)
≥ 65 years0.0092.102 (1.207–3.663)0.0351.835 (1.042–3.231)
Male0.5031.493 (0.463–4.816)  
Primary sites
 Larynx 1 (reference) 1 (reference)
 Hypopharynx0.0421.812 (1.022–3.213)0.7021.142 (0.580–2.248)
Smoking
 Never smoker 1 (reference)  
 Smoker0.6211.263 (0.500–3.190)  
Alcohol
 Non- or social- drinker 1 (reference)  
 Heavy drinker0.1601.772 (0.798–3.937)  
Differentiation
 Well 1 (reference) 1 (reference)
 Moderate0.0072.885 (1.343–6.199)0.0332.422 (1.076–5.452)
 Poor0.0263.180 (1.147–8.819)0.4221.398 (0.532–4.513)
Lymphovascular invasion0.0401.842 (1.029–3.296)0.5690.819 (0.411–1.632)
Perineural invasion0.0022.608 (1.411–4.821)0.0981.825 (0.896–3.720)
Positive resection margin0.0062.236 (1.265–3.951)0.0022.712 (1.425–5.161)
pT-classification
 pT1 1 (reference)  
 pT20.3581.464 (0.649–3.301)  
 pT30.0321.715 (1.076–5.171)  
 pT4a0.0112.224 (1.286–6.928)  
pN-classification
 pN0 1 (reference)  
 pN10.0852.385 (0.888–6.409)  
 pN20.0052.982 (1.382–6.431)  
 pN30.0013.003 (1.578–5.714)  
Pathological stage
 Stage I 1 (reference) 1 (reference)
 Stage II0.4821.561 (0.451–5.402)0.4571.625 (0.452–5.847)
 Stage III0.0113.890 (1.361–11.117)0.0483.018 (1.010–9.018)
 Stage IV0.0044.102 (1.591–10.581)0.0462.967 (1.018–8.647)
Adjuvant treatment0.6151.154 (0.661–2.013)  
p16 positivity0.1270.331 (0.080–1.368)  
FGFR1 amplification0.2522.128 (0.585–7.738)  
FGFR1 high expression0.3191.504 (0.674–3.354)  
  1. aAbbreviations: CI Confidence interval, HR Hazard ratio
  2. bVariables of the pT and pN classification were not included in the multivariate analysis, because they were included in the pathologic stage