Variables | Univariate | Multivariate | ||
---|---|---|---|---|
P value | HR (95% CI) | P value | HR (95% CI) | |
≥ 65 years | 0.009 | 2.102 (1.207–3.663) | 0.035 | 1.835 (1.042–3.231) |
Male | 0.503 | 1.493 (0.463–4.816) |  |  |
Primary sites | ||||
 Larynx |  | 1 (reference) |  | 1 (reference) |
 Hypopharynx | 0.042 | 1.812 (1.022–3.213) | 0.702 | 1.142 (0.580–2.248) |
Smoking | ||||
 Never smoker |  | 1 (reference) |  |  |
 Smoker | 0.621 | 1.263 (0.500–3.190) |  |  |
Alcohol | ||||
 Non- or social- drinker |  | 1 (reference) |  |  |
 Heavy drinker | 0.160 | 1.772 (0.798–3.937) |  |  |
Differentiation | ||||
 Well |  | 1 (reference) |  | 1 (reference) |
 Moderate | 0.007 | 2.885 (1.343–6.199) | 0.033 | 2.422 (1.076–5.452) |
 Poor | 0.026 | 3.180 (1.147–8.819) | 0.422 | 1.398 (0.532–4.513) |
Lymphovascular invasion | 0.040 | 1.842 (1.029–3.296) | 0.569 | 0.819 (0.411–1.632) |
Perineural invasion | 0.002 | 2.608 (1.411–4.821) | 0.098 | 1.825 (0.896–3.720) |
Positive resection margin | 0.006 | 2.236 (1.265–3.951) | 0.002 | 2.712 (1.425–5.161) |
pT-classification | ||||
 pT1 |  | 1 (reference) |  |  |
 pT2 | 0.358 | 1.464 (0.649–3.301) |  |  |
 pT3 | 0.032 | 1.715 (1.076–5.171) |  |  |
 pT4a | 0.011 | 2.224 (1.286–6.928) |  |  |
pN-classification | ||||
 pN0 |  | 1 (reference) |  |  |
 pN1 | 0.085 | 2.385 (0.888–6.409) |  |  |
 pN2 | 0.005 | 2.982 (1.382–6.431) |  |  |
 pN3 | 0.001 | 3.003 (1.578–5.714) |  |  |
Pathological stage | ||||
 Stage I |  | 1 (reference) |  | 1 (reference) |
 Stage II | 0.482 | 1.561 (0.451–5.402) | 0.457 | 1.625 (0.452–5.847) |
 Stage III | 0.011 | 3.890 (1.361–11.117) | 0.048 | 3.018 (1.010–9.018) |
 Stage IV | 0.004 | 4.102 (1.591–10.581) | 0.046 | 2.967 (1.018–8.647) |
Adjuvant treatment | 0.615 | 1.154 (0.661–2.013) |  |  |
p16 positivity | 0.127 | 0.331 (0.080–1.368) |  |  |
FGFR1 amplification | 0.252 | 2.128 (0.585–7.738) |  |  |
FGFR1 high expression | 0.319 | 1.504 (0.674–3.354) |  |  |