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Table 3 Cox proportional hazards regression model for disease-free survival in hypopharyngeal and laryngeal squamous cell carcinoma

From: Prognostic implications of Fibroblast growth factor receptor 1 (FGFR1) gene amplification and protein overexpression in hypopharyngeal and laryngeal squamous cell carcinoma

VariablesUnivariateMultivariate
P valueHR (95% CI)P valueHR (95% CI)
≥ 65 years0.4851.232 (0.686–2.211)  
Male0.9611.030 (0.319–3.324)  
Primary sites
 Larynx 1 (reference)  
 Hypopharynx0.3851.331 (0.698–2.536)  
Smoking
 Never smoker 1 (reference)  
 Smoker0.3680.690 (0.308–1.546)  
Alcohol
 Non- or social- drinker 1 (reference)  
 Heavy drinker0.1961.763 (0.746–4.164)  
Differentiation
 Well 1 (reference) 1 (reference)
 Moderate0.0572.148 (0.979–4.715)0.6871.340 (0.323–5.561)
 Poor0.0063.803 (1.466–9.864)0.8831.154 (0.170–7.839)
Lymphovascular invasion0.1201.669 (0.875–3.180)  
Perineural invasion0.0392.046 (1.035–4.040)0.6130.567 (0.063–5.119)
Positive resection margin0.0911.710 (0.919–3.185)  
pT-classification
 pT1 1 (reference)  
 pT20.9061.051 (0.463–2.384)  
 pT30.1781.715 (0.782–3.759)  
 pT4a0.0702.224 (0.936–5.282)  
pN-classification
 pN0 1 (reference)  
 pN10.0622.881 (0.948–8.757)  
 pN2<  0.0015.415 (2.492–11.769)  
 pN30.0052.816 (1.359–5.837)  
Pathological stage
 Stage I 1 (reference) 1 (reference)
 Stage II0.6860.756 (0.195–2.929)0.9041.147 (0.124–10.594)
 Stage III0.1682.089 (0.732–5.960)0.982< 0.001
 Stage IV0.0073.124 (1.364–7.153)0.2342.511 (0.551–11.438)
Adjuvant treatment0.3961.303 (0.707–2.400)  
p16 positivity0.7911.073 (0.637–1.806)  
FGFR1 amplification0.0174.204 (1.290–13.698)0.0493.666 (1.006–13.361)
FGFR1 high expression0.2351.633 (0.727–3.664)  
  1. aAbbreviations: CI Confidence interval, HR Hazard ratio
  2. bVariables of the pT and pN classification were not included in the multivariate analysis, because they were included in the pathologic stage