Variables | Univariate | Multivariate | ||
---|---|---|---|---|
P value | HR (95% CI) | P value | HR (95% CI) | |
≥ 65 years | 0.485 | 1.232 (0.686–2.211) |  |  |
Male | 0.961 | 1.030 (0.319–3.324) |  |  |
Primary sites | ||||
 Larynx |  | 1 (reference) |  |  |
 Hypopharynx | 0.385 | 1.331 (0.698–2.536) |  |  |
Smoking | ||||
 Never smoker |  | 1 (reference) |  |  |
 Smoker | 0.368 | 0.690 (0.308–1.546) |  |  |
Alcohol | ||||
 Non- or social- drinker |  | 1 (reference) |  |  |
 Heavy drinker | 0.196 | 1.763 (0.746–4.164) |  |  |
Differentiation | ||||
 Well |  | 1 (reference) |  | 1 (reference) |
 Moderate | 0.057 | 2.148 (0.979–4.715) | 0.687 | 1.340 (0.323–5.561) |
 Poor | 0.006 | 3.803 (1.466–9.864) | 0.883 | 1.154 (0.170–7.839) |
Lymphovascular invasion | 0.120 | 1.669 (0.875–3.180) |  |  |
Perineural invasion | 0.039 | 2.046 (1.035–4.040) | 0.613 | 0.567 (0.063–5.119) |
Positive resection margin | 0.091 | 1.710 (0.919–3.185) |  |  |
pT-classification | ||||
 pT1 |  | 1 (reference) |  |  |
 pT2 | 0.906 | 1.051 (0.463–2.384) |  |  |
 pT3 | 0.178 | 1.715 (0.782–3.759) |  |  |
 pT4a | 0.070 | 2.224 (0.936–5.282) |  |  |
pN-classification | ||||
 pN0 |  | 1 (reference) |  |  |
 pN1 | 0.062 | 2.881 (0.948–8.757) |  |  |
 pN2 | <  0.001 | 5.415 (2.492–11.769) |  |  |
 pN3 | 0.005 | 2.816 (1.359–5.837) |  |  |
Pathological stage | ||||
 Stage I |  | 1 (reference) |  | 1 (reference) |
 Stage II | 0.686 | 0.756 (0.195–2.929) | 0.904 | 1.147 (0.124–10.594) |
 Stage III | 0.168 | 2.089 (0.732–5.960) | 0.982 | < 0.001 |
 Stage IV | 0.007 | 3.124 (1.364–7.153) | 0.234 | 2.511 (0.551–11.438) |
Adjuvant treatment | 0.396 | 1.303 (0.707–2.400) |  |  |
p16 positivity | 0.791 | 1.073 (0.637–1.806) |  |  |
FGFR1 amplification | 0.017 | 4.204 (1.290–13.698) | 0.049 | 3.666 (1.006–13.361) |
FGFR1 high expression | 0.235 | 1.633 (0.727–3.664) |  |  |