Table 2 The status of FGFR1 gene amplification and protein overexpression in patients with hypopharyngeal and laryngeal squamous cell carcinoma
Characteristics | FGFR1 amplification, n = 66 | P value | FGFR1 high expression, n = 199 | P value | ||
|---|---|---|---|---|---|---|
Present, n (%) | Absent, n (%) | Present, n (%) | Absent, n (%) | |||
Total | 8 (12.1) | 58 (87.9) | Â | 21 (10.6) | 178 (89.4) | Â |
Primary sites | Â | Â | 0.015 | Â | Â | 0.307 |
 Hypopharynx | 6 (75.0) | 36 (62.1) |  | 6 (28.6) | 47 (26.4) |  |
 Larynx | 2 (25.0) | 22 (37.9) |  | 15 (71.4) | 131 (73.6) |  |
Gender | Â | Â | 0.771 | Â | Â | 0.145 |
 Female | 0 (0.0) | 2 (3.4) |  | 3 (14.3) | 10 (5.6) |  |
 Male | 8 (100.0) | 56 (96.6) |  | 18 (85.7) | 168 (94.4) |  |
Age (years) | Â | Â | 0.452 | Â | Â | 0.820 |
 Median (range) | 68.0 (55–73) | 63.0 (42–88) |  | 63.0 (45–78) | 64.0 (30–88) |  |
 < 65 | 3 (37.5) | 33 (56.9) |  | 12 (57.1) | 95 (53.4) |  |
 ≥ 65 | 5 (62.5) | 25 (43.1) |  | 9 (42.9) | 83 (46.6) |  |
Smoking | Â | Â | 0.405 | Â | Â | 0.302 |
 Never smoker | 2 (25.0) | 7 (12.1) |  | 3 (14.3) | 19 (10.7) |  |
 Former smoker | 1 (12.5) | 15 (25.9) |  | 6 (28.6) | 45 (25.3) |  |
 Current smoker | 5 (62.5) | 36 (62.1) |  | 12 (57.1) | 114 (64.0) |  |
Alcohol | Â | Â | 0.196 | Â | Â | 0.778 |
 Non- or social- drinker | 0 (0.0) | 13 (22.4) |  | 5 (23.8) | 37 (20.8) |  |
 Heavy drinker | 8 (100.0) | 45 (77.6) |  | 16 (76.2) | 141 (79.2) |  |
p16 status | Â | Â | 0.551 | Â | Â | 0.697 |
 Negative | 7 (87.5) | 47 (81.0) |  | 14 (82.4) | 131 (88.5) |  |
 Positive | 1 (12.5) | 11 (19.0) |  | 3 (17.6) | 17 (11.5) |  |
 Unknown | – |  |  |  |  |  |
Histologic differentiation |  |  | 0.355 |  |  | <  0.001 |
 Well differentiated | 2 (25.0) | 15 (25.9) |  | 1 (4.8) | 58 (32.6) |  |
 Moderately differentiated | 4 (50.0) | 37 (63.8) |  | 11 (52.4) | 108 (60.7) |  |
 Poorly differentiated | 2 (25.0) | 6 (10.3) |  | 9 (42.9) | 12 (6.7) |  |
Lymphovascular invasion | Â | Â | 0.031 | Â | Â | 0.096 |
 Absent | 4 (50.0) | 50 (86.2) |  | 13 (61.9) | 141 (79.2) |  |
 Present | 4 (50.0) | 8 (13.8) |  | 8 (38.1) | 37 (20.8) |  |
Perineural invasion | Â | Â | 0.614 | Â | Â | 0.335 |
 Absent | 7 (87.5) | 52 (89.7) |  | 16 (76.2) | 152 (85.4) |  |
 Present | 1 (12.5) | 6 (10.3) |  | 5 (23.8) | 26 (14.6) |  |
Positive resection margin | Â | Â | 0.537 | Â | Â | 0.494 |
 Absent | 4 (50.0) | 32 (55.2) |  | 16 (76.2) | 130 (73.0) |  |
 Present | 4 (50.0) | 26 (44.8) |  | 5 (23.8) | 48 (27.0) |  |
Pathological T-classification | Â | Â | 0.365 | Â | Â | 0.238 |
 pT1 | 3 (37.5) | 29 (50.0) |  | 4 (19.0) | 59 (33.1) |  |
 pT2 | 4 (50.0) | 18 (31.0) |  | 9 (42.9) | 49 (27.5) |  |
 pT3 | 0 (0.0) | 10 (17.2) |  | 4 (19.0) | 48 (27.0) |  |
 pT4a | 1 (9.1) | 1 (1.7) |  | 4 (19.0) | 22 (12.4) |  |
Pathological N-classification | Â | Â | 0.012 | Â | Â | 0.003 |
 pN0 | 3 (27.3) | 32 (58.2) |  | 6 (28.6) | 105 (59.0) |  |
 pN1 | 0 (0.0) | 4 (7.3) |  | 1 (4.8) | 12 (6.7) |  |
 pN2 | 1 (9.1) | 7 (12.7) |  | 4 (19.0) | 22 (12.4) |  |
 pN3 | 7 (63.6) | 12 (21.8) |  | 10 (47.6) | 39 (21.9) |  |
Pathological stage | Â | Â | 0.047 | Â | Â | 0.001 |
 Stage I | 2 (25.0) | 24 (41.4) |  | 1 (4.8) | 53 (29.8) |  |
 Stage II | 0 (0.0) | 5 (8.6) |  | 3 (14.3) | 26 (14.6) |  |
 Stage III | 0 (0.0) | 7 (12.1) |  | 2 (9.5) | 30 (16.9) |  |
 Stage IVA | 1 (12.5) | 8 (13.8) |  | 5 (23.8) | 30 (16.9) |  |
 Stage IVB | 5 (62.5) | 14 (24.1) |  | 10 (47.6) | 39 (21.9) |  |
Recurrence | Â | Â | 0.042 | Â | Â | 0.263 |
 No | 4 (50.0) | 49 (84.5) |  | 14 (66.7) | 141 (79.2) |  |
 Yes | 4 (50.0) | 9 (15.5) |  | 7 (33.3) | 37 (20.8) |  |
 Local recurrence only | 2 (50.0) | 5 (55.6) |  | 2 (28.6) | 20 (54.1) |  |
 Distant recurrence | 2 (50.0) | 4 (44.4) |  | 5 (71.4) | 17 (45.9) |  |