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Table 2 The status of FGFR1 gene amplification and protein overexpression in patients with hypopharyngeal and laryngeal squamous cell carcinoma

From: Prognostic implications of Fibroblast growth factor receptor 1 (FGFR1) gene amplification and protein overexpression in hypopharyngeal and laryngeal squamous cell carcinoma

Characteristics

FGFR1 amplification, n = 66

P value

FGFR1 high expression, n = 199

P value

Present, n (%)

Absent, n (%)

Present, n (%)

Absent, n (%)

Total

8 (12.1)

58 (87.9)

 

21 (10.6)

178 (89.4)

 

Primary sites

  

0.015

  

0.307

 Hypopharynx

6 (75.0)

36 (62.1)

 

6 (28.6)

47 (26.4)

 

 Larynx

2 (25.0)

22 (37.9)

 

15 (71.4)

131 (73.6)

 

Gender

  

0.771

  

0.145

 Female

0 (0.0)

2 (3.4)

 

3 (14.3)

10 (5.6)

 

 Male

8 (100.0)

56 (96.6)

 

18 (85.7)

168 (94.4)

 

Age (years)

  

0.452

  

0.820

 Median (range)

68.0 (55–73)

63.0 (42–88)

 

63.0 (45–78)

64.0 (30–88)

 

 < 65

3 (37.5)

33 (56.9)

 

12 (57.1)

95 (53.4)

 

 ≥ 65

5 (62.5)

25 (43.1)

 

9 (42.9)

83 (46.6)

 

Smoking

  

0.405

  

0.302

 Never smoker

2 (25.0)

7 (12.1)

 

3 (14.3)

19 (10.7)

 

 Former smoker

1 (12.5)

15 (25.9)

 

6 (28.6)

45 (25.3)

 

 Current smoker

5 (62.5)

36 (62.1)

 

12 (57.1)

114 (64.0)

 

Alcohol

  

0.196

  

0.778

 Non- or social- drinker

0 (0.0)

13 (22.4)

 

5 (23.8)

37 (20.8)

 

 Heavy drinker

8 (100.0)

45 (77.6)

 

16 (76.2)

141 (79.2)

 

p16 status

  

0.551

  

0.697

 Negative

7 (87.5)

47 (81.0)

 

14 (82.4)

131 (88.5)

 

 Positive

1 (12.5)

11 (19.0)

 

3 (17.6)

17 (11.5)

 

 Unknown

     

Histologic differentiation

  

0.355

  

<  0.001

 Well differentiated

2 (25.0)

15 (25.9)

 

1 (4.8)

58 (32.6)

 

 Moderately differentiated

4 (50.0)

37 (63.8)

 

11 (52.4)

108 (60.7)

 

 Poorly differentiated

2 (25.0)

6 (10.3)

 

9 (42.9)

12 (6.7)

 

Lymphovascular invasion

  

0.031

  

0.096

 Absent

4 (50.0)

50 (86.2)

 

13 (61.9)

141 (79.2)

 

 Present

4 (50.0)

8 (13.8)

 

8 (38.1)

37 (20.8)

 

Perineural invasion

  

0.614

  

0.335

 Absent

7 (87.5)

52 (89.7)

 

16 (76.2)

152 (85.4)

 

 Present

1 (12.5)

6 (10.3)

 

5 (23.8)

26 (14.6)

 

Positive resection margin

  

0.537

  

0.494

 Absent

4 (50.0)

32 (55.2)

 

16 (76.2)

130 (73.0)

 

 Present

4 (50.0)

26 (44.8)

 

5 (23.8)

48 (27.0)

 

Pathological T-classification

  

0.365

  

0.238

 pT1

3 (37.5)

29 (50.0)

 

4 (19.0)

59 (33.1)

 

 pT2

4 (50.0)

18 (31.0)

 

9 (42.9)

49 (27.5)

 

 pT3

0 (0.0)

10 (17.2)

 

4 (19.0)

48 (27.0)

 

 pT4a

1 (9.1)

1 (1.7)

 

4 (19.0)

22 (12.4)

 

Pathological N-classification

  

0.012

  

0.003

 pN0

3 (27.3)

32 (58.2)

 

6 (28.6)

105 (59.0)

 

 pN1

0 (0.0)

4 (7.3)

 

1 (4.8)

12 (6.7)

 

 pN2

1 (9.1)

7 (12.7)

 

4 (19.0)

22 (12.4)

 

 pN3

7 (63.6)

12 (21.8)

 

10 (47.6)

39 (21.9)

 

Pathological stage

  

0.047

  

0.001

 Stage I

2 (25.0)

24 (41.4)

 

1 (4.8)

53 (29.8)

 

 Stage II

0 (0.0)

5 (8.6)

 

3 (14.3)

26 (14.6)

 

 Stage III

0 (0.0)

7 (12.1)

 

2 (9.5)

30 (16.9)

 

 Stage IVA

1 (12.5)

8 (13.8)

 

5 (23.8)

30 (16.9)

 

 Stage IVB

5 (62.5)

14 (24.1)

 

10 (47.6)

39 (21.9)

 

Recurrence

  

0.042

  

0.263

 No

4 (50.0)

49 (84.5)

 

14 (66.7)

141 (79.2)

 

 Yes

4 (50.0)

9 (15.5)

 

7 (33.3)

37 (20.8)

 

 Local recurrence only

2 (50.0)

5 (55.6)

 

2 (28.6)

20 (54.1)

 

 Distant recurrence

2 (50.0)

4 (44.4)

 

5 (71.4)

17 (45.9)