Fig. 3

Right-colon specific transcriptomic (dys) regulation. a. Enrichment of hallmark gene sets within genes uniquely downregulated within RSCC identifies a marked suppression of genes particularly associated with metabolism (bile, xenobiotic and fatty acid). b. Box and whisker plots of gene expression counts (stage agnostic) for 3 genes (CYP2C8/18 and CYP4F12) suppressed in right tumors compared to their respective normal tissue. c. Stage specific expression (fold changes) for select genes discussed in main text associated with xenobiotic metabolism, captured across stages (T1-T4) in RSCC. Grey indicates non-significant expression (see Methods)