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Fig. 3 | BMC Cancer

Fig. 3

From: The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib

Fig. 3

Predicted dose reduction of ATP-pocket TKI + asciminib combinations that are as effective as standard therapy. Grey lines shows effects assuming the combination has an exclusive interaction (Eq. 2) and black lines show a nonexclusive combination (Eq. 3). The latter is more likely for the combinations shown. Depending on whether the drugs are given simultaneously or in a staggered manner the effect changes. Dashed lines were calculated for a simultaneous administration whereas for the full lines the offset between taking one drug and the other was optimised to improve the dose reduction potential. a: A dasatinib-asciminib combination has a good dose reduction potential but it is sensitive to variations in administration timing and performs much better with a staggered administration schedule (b, c). d–g: Other combinations (imatinib, nilotinib, bosutinib and ponatinib, each combined with asciminib) perform similarly to one another, and are not very sensitive to administration timing (data not shown)

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