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Table 3 Univariate and multivariate analysis for overall survival

From: Perineural invasion as a prognostic factor for intrahepatic cholangiocarcinoma after curative resection and a potential indication for postoperative chemotherapy: a retrospective cohort study

VariableReferenceUnivariate COX regressionMultivariate COX regression
HR (95% CI)PHR (95% CI)P
Age< 600.861 (0.555, 1.335)0.503  
GenderFemale0.709 (0.461, 1.091)0.118  
LocationHilar1.138 (0.648, 1.996)0.653  
HBsAgNegative0.817 (0.508, 1.315)0.406  
Tumor size (cm)≤51.798 (1.135, 2.849)0.0120.115
Multiple tumorNo1.804 (1.136, 2.867)0.0120.551
Vascular invasionNegative1.297 (0.838, 2.006)0.243  
Perineural invasionNegative2.515 (1.592, 3.975)0.0001.747 (1.080, 2.826)0.023
Capsular invasionNegative1.391 (0.905, 2.140)0.133  
Visceral invasionNegative1.646 (0.971, 2.790)0.0640.718
AJCC T stageT1 and T21.332 (0.865, 2.050)0.193  
AJCC N stageN0 and Nx2.805 (1.717, 4.585)0.0000.331
AJCC stageI    
 Stage II 4.876(2.239, 10.617)0.0003.307 (1.466, 7.460)0.004
 Stage III 3.473 (1.814, 6.647)0.0002.799 (1.444, 5.424)0.002
Tumor differentiationWell to moderate1.923 (1.179, 3.139)0.0092.179 (1.309, 3.626)0.003
Liver cirrhosisNegative1.297 (0.837, 2.011)0.245  
ALT (U/L)≤401.272 (0.816, 1.982)0.289  
AST (U/L)≤401.463 (0.942, 2.274)0.0911.612 (1.003, 2.590)0.049
PLT (×10^9/L)≤3001.834 (1.122, 2.997)0.0160.156
CEA (ng/ml)≤51.936 (1.213, 3.092)0.0060.114
CA19–9 (U/ml)≤2003.220 (2.057, 5.042)0.0002.911 (1.798, 4.712)0.000
CA24–2 (U/ml)≤202.427 (1.554, 3.790)0.0000.983
Child-Pugh classificationA1.355 (0.762, 2.411)0.301  
Postoperative chemotherapyNo0.180 (0.057, 0.573)0.0040.174 (0.054, 0.566)0.004
Post-recurrence anti-tumor therapyNo0.871 (0.557, 1.361)0.543  
  1. HR hazard ratio, CI confidence interval, PNI perineural invasion, HBsAg hepatitis B surface antigen, AJCC American Joint Committee on Cancer, ALT Alanine aminotransferase, AST Aspartate aminotransferase, PLT Blood platelet, CEA Carcinoembryonic antigen