Variable | Reference | Univariate COX regression | Multivariate COX regression | ||
---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||
Age | < 60 | 0.861 (0.555, 1.335) | 0.503 | ||
Gender | Female | 0.709 (0.461, 1.091) | 0.118 | ||
Location | Hilar | 1.138 (0.648, 1.996) | 0.653 | ||
HBsAg | Negative | 0.817 (0.508, 1.315) | 0.406 | ||
Tumor size (cm) | ≤5 | 1.798 (1.135, 2.849) | 0.012 | – | 0.115 |
Multiple tumor | No | 1.804 (1.136, 2.867) | 0.012 | – | 0.551 |
Vascular invasion | Negative | 1.297 (0.838, 2.006) | 0.243 | ||
Perineural invasion | Negative | 2.515 (1.592, 3.975) | 0.000 | 1.747 (1.080, 2.826) | 0.023 |
Capsular invasion | Negative | 1.391 (0.905, 2.140) | 0.133 | ||
Visceral invasion | Negative | 1.646 (0.971, 2.790) | 0.064 | – | 0.718 |
AJCC T stage | T1 and T2 | 1.332 (0.865, 2.050) | 0.193 | ||
AJCC N stage | N0 and Nx | 2.805 (1.717, 4.585) | 0.000 | – | 0.331 |
AJCC stage | I | ||||
Stage II | 4.876(2.239, 10.617) | 0.000 | 3.307 (1.466, 7.460) | 0.004 | |
Stage III | 3.473 (1.814, 6.647) | 0.000 | 2.799 (1.444, 5.424) | 0.002 | |
Tumor differentiation | Well to moderate | 1.923 (1.179, 3.139) | 0.009 | 2.179 (1.309, 3.626) | 0.003 |
Liver cirrhosis | Negative | 1.297 (0.837, 2.011) | 0.245 | ||
ALT (U/L) | ≤40 | 1.272 (0.816, 1.982) | 0.289 | ||
AST (U/L) | ≤40 | 1.463 (0.942, 2.274) | 0.091 | 1.612 (1.003, 2.590) | 0.049 |
PLT (×10^9/L) | ≤300 | 1.834 (1.122, 2.997) | 0.016 | – | 0.156 |
CEA (ng/ml) | ≤5 | 1.936 (1.213, 3.092) | 0.006 | – | 0.114 |
CA19–9 (U/ml) | ≤200 | 3.220 (2.057, 5.042) | 0.000 | 2.911 (1.798, 4.712) | 0.000 |
CA24–2 (U/ml) | ≤20 | 2.427 (1.554, 3.790) | 0.000 | – | 0.983 |
Child-Pugh classification | A | 1.355 (0.762, 2.411) | 0.301 | ||
Postoperative chemotherapy | No | 0.180 (0.057, 0.573) | 0.004 | 0.174 (0.054, 0.566) | 0.004 |
Post-recurrence anti-tumor therapy | No | 0.871 (0.557, 1.361) | 0.543 |