Table 2 Univariate and multivariate analysis for recurrence-free survival
Variable | Reference | Univariate COX regression | Multivariate COX regression | ||
|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||
Age | < 60 | 0.743 (0.492, 1.121) | 0.156 | ||
Gender | Female | 0.894 (0.598, 1.335) | 0.894 | ||
Location | Hilar | 1.186 (0.701, 2.004) | 0.525 | ||
HBsAg | Negative | 0.909 (0.585, 1.412) | 0.671 | ||
Tumor size (cm) | ≤5 | 1.913 (1.250, 2.928) | 0.003 | 1.834 (1.152, 2.920) | 0.011 |
Multiple tumor | No | 1.699 (1.100, 2.625) | 0.017 | 1.701 (1.060, 2.731) | 0.028 |
Vascular invasion | Negative | 1.473 (0.982, 2.210) | 0.061 | – | 0.138 |
Perineural invasion | Negative | 2.504 (1.634, 3.836) | 0.000 | 2.562 (1.564, 4.199) | 0.000 |
Capsular invasion | Negative | 1.345 (0.900, 2.010) | 0.148 | ||
Visceral invasion | Negative | 1.416 (0.855, 2.345) | 0.177 | ||
AJCC T stage | T1 and T2 | 1.305 (0.874, 1.949) | 0.193 | ||
AJCC N stage | N0 and Nx | 2.449 (1.542, 3.891) | 0.000 | 1.742 (1.050, 2.891) | 0.032 |
AJCC stage | I | ||||
Stage II | 2.784 (1.415, 5.477) | 0.003 | – | 0.633 | |
Stage III | 2.333 (1.378, 3.950) | 0.002 | – | 0.266 | |
Tumor differentiation | Well to moderate | 2.140 (1.366, 3.352) | 0.001 | 2.796 (1.718, 4.550) | 0.000 |
Liver cirrhosis | Negative | 1.463 (0.971, 2.204) | 0.069 | 1.992 (1.264, 3.139) | 0.003 |
ALT (U/L) | ≤40 | 1.074 (0.710, 1.624) | 0.737 | ||
AST (U/L) | ≤40 | 1.158 (0.763, 1.757) | 0.490 | ||
PLT (×10^9/L) | ≤300 | 1.411 (0.874, 2.276) | 0.159 | ||
CEA (ng/ml) | ≤5 | 1.698 (1.085, 2.657) | 0.020 | – | 0.737 |
CA19–9 (U/ml) | ≤200 | 2.784 (1.841, 4.209) | 0.000 | 2.625 (1.624, 4.243) | 0.000 |
CA24–2 (U/ml) | ≤20 | 2.147 (1.426, 3.232) | 0.000 | – | 0.568 |
Child-Pugh classification | A | 1.016 (0.575, 1.794) | 0.957 | ||
Postoperative chemotherapy | No | 0.296 (0.129, 0.680) | 0.004 | 0.282 (0.119, 0.668) | 0.004 |