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Table 2 Univariate and multivariate analysis for recurrence-free survival

From: Perineural invasion as a prognostic factor for intrahepatic cholangiocarcinoma after curative resection and a potential indication for postoperative chemotherapy: a retrospective cohort study

VariableReferenceUnivariate COX regressionMultivariate COX regression
HR (95% CI)PHR (95% CI)P
Age< 600.743 (0.492, 1.121)0.156  
GenderFemale0.894 (0.598, 1.335)0.894  
LocationHilar1.186 (0.701, 2.004)0.525  
HBsAgNegative0.909 (0.585, 1.412)0.671  
Tumor size (cm)≤51.913 (1.250, 2.928)0.0031.834 (1.152, 2.920)0.011
Multiple tumorNo1.699 (1.100, 2.625)0.0171.701 (1.060, 2.731)0.028
Vascular invasionNegative1.473 (0.982, 2.210)0.0610.138
Perineural invasionNegative2.504 (1.634, 3.836)0.0002.562 (1.564, 4.199)0.000
Capsular invasionNegative1.345 (0.900, 2.010)0.148  
Visceral invasionNegative1.416 (0.855, 2.345)0.177  
AJCC T stageT1 and T21.305 (0.874, 1.949)0.193  
AJCC N stageN0 and Nx2.449 (1.542, 3.891)0.0001.742 (1.050, 2.891)0.032
AJCC stageI    
 Stage II 2.784 (1.415, 5.477)0.0030.633
 Stage III 2.333 (1.378, 3.950)0.0020.266
Tumor differentiationWell to moderate2.140 (1.366, 3.352)0.0012.796 (1.718, 4.550)0.000
Liver cirrhosisNegative1.463 (0.971, 2.204)0.0691.992 (1.264, 3.139)0.003
ALT (U/L)≤401.074 (0.710, 1.624)0.737  
AST (U/L)≤401.158 (0.763, 1.757)0.490  
PLT (×10^9/L)≤3001.411 (0.874, 2.276)0.159  
CEA (ng/ml)≤51.698 (1.085, 2.657)0.0200.737
CA19–9 (U/ml)≤2002.784 (1.841, 4.209)0.0002.625 (1.624, 4.243)0.000
CA24–2 (U/ml)≤202.147 (1.426, 3.232)0.0000.568
Child-Pugh classificationA1.016 (0.575, 1.794)0.957  
Postoperative chemotherapyNo0.296 (0.129, 0.680)0.0040.282 (0.119, 0.668)0.004
  1. HR hazard ratio, CI confidence interval, PNI perineural invasion, HBsAg hepatitis B surface antigen, AJCC American Joint Committee on Cancer, ALT Alanine aminotransferase, AST Aspartate aminotransferase, PLT Blood platelet, CEA Carcinoembryonic antigen