Table 5 Association of RIPK1 gene polymorphisms with cervical cancer susceptibility after stratifying by age and stage
From: RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China
SNP | Model | Age (Cases Vs. Controls) | Stage (III/IV Vs. I/II) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
> 43 (176 Vs. 263) | ≤ 43 (166 Vs. 235) | 80 Vs. 132 | ||||||||
OR (95%CI) | p Value | FDR-p Value | OR (95%CI) | p Value | FDR-p Value | OR (95%CI) | p Value | FDR-p Value | ||
rs6907943 | Allele (15.91–14.83%/84.09–85.17%) | 1.09 (0.75–1.58) | 0.663 | 0.796 | 0.93 (0.63–1.37) | 0.705 | 0.705 | 0.47 (0.24–0.90) | 0.021 | 0.041 |
Codominant | 1.91 (0.69–5.26) | 0.211 | 0.633 | 1.35 (0.42–4.29) | 0.614 | 0.705 | – | – | – | |
0.89 (0.56–1.42) | 0.629 | 0.796 | 0.80 (0.50–1.27) | 0.335 | 0.705 | 0.50 (0.25–1.02) | 0.056 | 0.056 | ||
Dominant | 0.99 (0.65–1.53) | 0.979 | 0.979 | 0.84 (0.54–1.31) | 0.449 | 0.705 | 0.46 (0.23–0.93) | 0.031 | 0.041 | |
Recessive | 1.96 (0.72–5.37) | 0.190 | 0.633 | 1.43 (0.45–4.53) | 0.542 | 0.705 | – | – | – | |
Log-additive | 1.08 (0.76–1.55) | 0.656 | 0.796 | 0.92 (0.63–1.34) | 0.650 | 0.705 | 0.46 (0.23–0.89) | 0.022 | 0.041 | |
rs2077681 | Allele (18.57–15.46%/81.43–84.54%) | 1.25 (0.87–1.79) | 0.227 | 0.387 | 1.16 (0.80–1.68) | 0.430 | 0.698 | 0.69 (0.40–1.20) | 0.187 | 0.306 |
Codominant | 3.38 (1.15–9.99) | 0.027 | 0.081 | 2.83 (0.83–9.66) | 0.096 | 0.288 | 1.39 (0.33–5.77) | 0.652 | 0.652 | |
0.92 (0.59–1.43) | 0.708 | 0.717 | 0.94 (0.60–1.47) | 0.779 | 0.851 | 0.47 (0.24–0.94) | 0.034 | 0.204 | ||
Dominant | 1.08 (0.71–1.64) | 0.717 | 0.717 | 1.04 (0.68–1.6) | 0.851 | 0.851 | 0.55 (0.29–1.05) | 0.070 | 0.210 | |
Recessive | 3.46 (1.18–10.15) | 0.024 | 0.081 | 2.89 (0.85–9.77) | 0.088 | 0.288 | 1.67 (0.41–6.89) | 0.478 | 0.574 | |
Log-additive | 1.22 (0.86–1.73) | 0.258 | 0.387 | 1.15 (0.79–1.66) | 0.465 | 0.698 | 0.71 (0.42–1.21) | 0.204 | 0.306 | |
rs9503400 | Allele (6.25–4.94%/93.75–95.06%) | 1.28 (0.71–2.30) | 0.404 | 0.404 | 1.45 (0.80–2.63) | 0.222 | 0.347 | 3.42 (1.55–7.56) | 0.001 | 0.004 |
Codominant | – | – | – | 4.41 (0.45–42.80) | 0.201 | 0.347 | – | – | – | |
– | – | – | 1.21 (0.61–2.37) | 0.585 | 0.585 | 3.37 (1.45–7.82) | 0.005 | 0.005 | ||
Dominant | 1.30 (0.71–2.38) | 0.392 | 0.404 | 1.36 (0.71–2.58) | 0.355 | 0.426 | 3.57 (1.55–8.22) | 0.003 | 0.004 | |
Recessive | – | – | – | 4.33 (0.45–41.98) | 0.207 | 0.347 | – | – | – | |
Log-additive | 1.30 (0.71–2.38) | 0.392 | 0.404 | 1.41 (0.80–2.49) | 0.231 | 0.347 | 3.53 (1.56–7.98) | 0.002 | 0.004 | |
rs17548629 | Allele (14.49–12.36%/85.51–87.64%) | 1.20 (0.81–1.78) | 0.361 | 0.579 | 0.74 (0.49–1.12) | 0.153 | 0.355 | 0.41 (0.21–0.83) | 0.011 | 0.036 |
Codominant | 3.99 (1.04–15.32) | 0.044 | 0.132 | 0.44 (0.09–2.20) | 0.315 | 0.355 | – | – | – | |
0.89 (0.56–1.44) | 0.645 | 0.774 | 0.76 (0.48–1.22) | 0.256 | 0.355 | 0.52 (0.24–1.10) | 0.086 | 0.086 | ||
Dominant | 1.05 (0.67–1.63) | 0.846 | 0.846 | 0.73 (0.47–1.16) | 0.185 | 0.355 | 0.44 (0.21–0.93) | 0.031 | 0.041 | |
Recessive | 4.09 (1.07–15.63) | 0.040 | 0.132 | 0.47 (0.09–2.34) | 0.355 | 0.355 | – | – | – | |
Log-additive | 1.19 (0.81–1.74) | 0.386 | 0.579 | 0.74 (0.49–1.11) | 0.147 | 0.355 | 0.43 (0.22–0.87) | 0.018 | 0.036 | |