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Table 5 Association of RIPK1 gene polymorphisms with cervical cancer susceptibility after stratifying by age and stage

From: RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China

SNPModelAge (Cases Vs. Controls)Stage (III/IV Vs. I/II)
> 43 (176 Vs. 263)≤ 43 (166 Vs. 235)80 Vs. 132
OR (95%CI)p ValueFDR-p ValueOR (95%CI)p ValueFDR-p ValueOR (95%CI)p ValueFDR-p Value
rs6907943Allele (15.91–14.83%/84.09–85.17%)1.09 (0.75–1.58)0.6630.7960.93 (0.63–1.37)0.7050.7050.47 (0.24–0.90)0.0210.041
Codominant1.91 (0.69–5.26)0.2110.6331.35 (0.42–4.29)0.6140.705
 0.89 (0.56–1.42)0.6290.7960.80 (0.50–1.27)0.3350.7050.50 (0.25–1.02)0.0560.056
Dominant0.99 (0.65–1.53)0.9790.9790.84 (0.54–1.31)0.4490.7050.46 (0.23–0.93)0.0310.041
Recessive1.96 (0.72–5.37)0.1900.6331.43 (0.45–4.53)0.5420.705
Log-additive1.08 (0.76–1.55)0.6560.7960.92 (0.63–1.34)0.6500.7050.46 (0.23–0.89)0.0220.041
rs2077681Allele (18.57–15.46%/81.43–84.54%)1.25 (0.87–1.79)0.2270.3871.16 (0.80–1.68)0.4300.6980.69 (0.40–1.20)0.1870.306
Codominant3.38 (1.15–9.99)0.0270.0812.83 (0.83–9.66)0.0960.2881.39 (0.33–5.77)0.6520.652
 0.92 (0.59–1.43)0.7080.7170.94 (0.60–1.47)0.7790.8510.47 (0.24–0.94)0.0340.204
Dominant1.08 (0.71–1.64)0.7170.7171.04 (0.68–1.6)0.8510.8510.55 (0.29–1.05)0.0700.210
Recessive3.46 (1.18–10.15)0.0240.0812.89 (0.85–9.77)0.0880.2881.67 (0.41–6.89)0.4780.574
Log-additive1.22 (0.86–1.73)0.2580.3871.15 (0.79–1.66)0.4650.6980.71 (0.42–1.21)0.2040.306
rs9503400Allele
(6.25–4.94%/93.75–95.06%)
1.28 (0.71–2.30)0.4040.4041.45 (0.80–2.63)0.2220.3473.42 (1.55–7.56)0.0010.004
Codominant4.41 (0.45–42.80)0.2010.347
 1.21 (0.61–2.37)0.5850.5853.37 (1.45–7.82)0.0050.005
Dominant1.30 (0.71–2.38)0.3920.4041.36 (0.71–2.58)0.3550.4263.57 (1.55–8.22)0.0030.004
Recessive4.33 (0.45–41.98)0.2070.347
Log-additive1.30 (0.71–2.38)0.3920.4041.41 (0.80–2.49)0.2310.3473.53 (1.56–7.98)0.0020.004
rs17548629Allele
(14.49–12.36%/85.51–87.64%)
1.20 (0.81–1.78)0.3610.5790.74 (0.49–1.12)0.1530.3550.41 (0.21–0.83)0.0110.036
Codominant3.99 (1.04–15.32)0.0440.1320.44 (0.09–2.20)0.3150.355
 0.89 (0.56–1.44)0.6450.7740.76 (0.48–1.22)0.2560.3550.52 (0.24–1.10)0.0860.086
Dominant1.05 (0.67–1.63)0.8460.8460.73 (0.47–1.16)0.1850.3550.44 (0.21–0.93)0.0310.041
Recessive4.09 (1.07–15.63)0.0400.1320.47 (0.09–2.34)0.3550.355
Log-additive1.19 (0.81–1.74)0.3860.5790.74 (0.49–1.11)0.1470.3550.43 (0.22–0.87)0.0180.036
  1. SNP Sing nucleotide polymorphism, OR Odds ratios, CI Confidence intervals, FDR False discovery rate
  2. Bold italics indicates the SNP with statistical significance (p < 0.05)