Fig. 2

Genomic regions in primary CRCs or CRC liver metastases displaying differential methylation relative to that in normal colon mucosa (NM). a and b. Differentially methylated regions (DMRs) characterized by hypermethylation and hypomethylation (vs. NM) present in primary CRCs, metastatic CRCs, or both. c, d, e, and f. Distributions of hypermethylated and hypomethylated DMRs in the extragenic vs. intragenic genomes; among the intragenic genome components; between the sSISs and extra-sSISs genomic segments, and among the sSISs components, respectively. (See Figure 1 for topography of genomic segments.)