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Fig. 1 | BMC Cancer

Fig. 1

From: The DNA hypermethylation phenotype of colorectal cancer liver metastases resembles that of the primary colorectal cancers

Fig. 1

Genomic distribution and functional classification of MBD-captured regions within the genome. a. Schematic showing components of an "intragenic" genomic region. Areas outside such regions were classified as "extragenic". b. MBD-captured regions (total: 322,551) classified as extragenic vs. intragenic. c. Distribution of the 206,258 intragenic MBD-captured regions by subregions: gene regulatory (including 5'UTRs and regions 5 kb upstream from the TSS); gene body (including exonic and intronic sequences between the end of the 5'UTR and the beginning of the 3'UTR); and the 3'UTRs. d. Schematic showing components of an “sSISs” region (i.e., a CpG island and flanking CpG shores and shelves). Areas outside such regions were defined "extra-sSISs". Schematics in this panel and in panel A were adapted from diagrams contained in the R-package annotatr vignette.e. MBD-captured regions classified as sSISs vs. extra-sSISs. f. Distribution of the 53,521 sSISs MBD-captured regions by subregions (CpG islands, shores, and shelves). N.B. After exclusion of the X and Y chromosomes, the human genome contains 26,361 canonical CpG islands, 15,423 of which were covered by MBDE. (See Discussion).

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