Table 2 Previously described relationships between metabolites included in gene nodes and the function of these nodes
Metabolite | Node | Described relationship | Reference |
|---|---|---|---|
Succinate | Immune response | Increases immune response, induces IL-1b production, promotes adaptive immune response. | PMID: 28109906 |
Cytidine | Immune response | 5-aza-2′-deoxycytidine potentiates antitumor immune response, role in innate immune response. | PMID: 23865062, PMID: 24559534 |
Histamine | Angiogenesis | Histamine promotes angiogenesis by enhancing VEGF production. | PMID: 23225320 |
1,2-propanediol (prev.X-4796) | Angiogenesis | Modulates the immune system through S1P, which promotes angiogenesis and proliferation. 14C-sulfoquinovosyl acylpropanediol is an antiangiogenic drug. | PMID: 21632869, PMID: 29543539 |