Fig. 1

Timeline of patient 1. Neutrophil count over time following administration of ipilimumab, nivolumab and metamizol as well as subsequent interventions (application of G-CSF and methylprednisolone) are shown. The lower grey band marks the thresholds of neutrophils in the blood. The upper grey band shows concurrent diarrhoea that was intermittently active between and during events of neutropenia. Numbers in yellow indicate the time point of positron emission tomography (PET) with images shown in Fig. 2. The black cross marks the death of the patient