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Table 6 Univariate Cox proportional hazard regression analysis of clinicopathological features and immunological markers with disease-free survival (DFS) or overall survival (OS) in subgroup of undifferentiated WHO type III LA-NPC patients (n = 58)

From: CD3+T-lymphocyte infiltration is an independent prognostic factor for advanced nasopharyngeal carcinoma

 

Relapse

DFS

Death

OS

+

HR

(95% CI)

*P

+

HR

(95% CI)

P

Total TIL

 High

29 (83)

6 (17)

1

  

33 (94)

2 (6)

1

  

 Low

13 (56)

10 (44)

3.1

1.1–9.1

0.029

17 (74)

6 (26)

4.3

1–29.6

0.075

CD3+ TIL

 High

32 (89)

4 (11)

1

  

35 (97)

1 (3)

1

  

 Low

10 (45)

12 (55)

7.2

2.5–25.7

< 0.001

15 (68)

7 (32)

17.3

3.0–324.4

0.008

CD8+ TIL

 High

35 (83)

7 (17)

1

  

40 (95)

2 (5)

1

  

 Low

7 (44)

9 (56)

4.3

1.6–11.9

0.004

10 (62)

6 (38)

7.5

1.7–51.3

0.014

PD-L1+ tumor cells (mem or cyto)║

 Positive (≥ 10%)

32 (76)

10 (24)

1

  

39 (93)

3 (7)

1

  

 Negative (<  10%)

10 (63)

6 (37)

1.7

0.6–4.5

0.313

11 (69)

5 (31)

6.1

1.3–42.7

0.031

  1. Abbreviations: (+ and -) are number of positive and negative patients, Numbers between brackets are the percentages of patients, *P values in bold represent significant data. mem = membranous, cyto = cytoplasmic