Relapse | DFS | Death | OS | |||||||
---|---|---|---|---|---|---|---|---|---|---|
– | + | HR | (95% CI) | *P | – | + | HR | (95% CI) | P | |
Total TIL | ||||||||||
High | 29 (83)♣ | 6 (17) | 1 | 33 (94) | 2 (6) | 1 | ||||
Low | 13 (56) | 10 (44) | 3.1 | 1.1–9.1 | 0.029 | 17 (74) | 6 (26) | 4.3 | 1–29.6 | 0.075 |
CD3+ TIL | ||||||||||
High | 32 (89) | 4 (11) | 1 | 35 (97) | 1 (3) | 1 | ||||
Low | 10 (45) | 12 (55) | 7.2 | 2.5–25.7 | < 0.001 | 15 (68) | 7 (32) | 17.3 | 3.0–324.4 | 0.008 |
CD8+ TIL | ||||||||||
High | 35 (83) | 7 (17) | 1 | 40 (95) | 2 (5) | 1 | ||||
Low | 7 (44) | 9 (56) | 4.3 | 1.6–11.9 | 0.004 | 10 (62) | 6 (38) | 7.5 | 1.7–51.3 | 0.014 |
PD-L1+ tumor cells (mem or cyto)║ | ||||||||||
Positive (≥ 10%) | 32 (76) | 10 (24) | 1 | 39 (93) | 3 (7) | 1 | ||||
Negative (< 10%) | 10 (63) | 6 (37) | 1.7 | 0.6–4.5 | 0.313 | 11 (69) | 5 (31) | 6.1 | 1.3–42.7 | 0.031 |