Table 4 Univariate Cox proportional hazard regression analysis of clinicopathological features and immunological markers with disease-free survival (DFS) and Overall Survival (OS) in 63 patients with LA-NPC at the time of presentation

 40 years

17 (74)^♣

6 (26)

1

21 (91)

2 (9)

1

  ≥ 40 years

25 (62)

15 (38)

1.47

0.57–3.8

0.424

32 (80)

8 (20)

2.0

0.42–9.70

0.383

 III

42 (72)

16 (28)

1

50 (86)

8 (14)

1

 I & II

0 (0)

5 (100)

4.0

1.42–11.4

0.008

3 (60)

2 (40)

1.0

0.12–8.1

0.999

 1&2

18 (86)

3 (14)

1

0.125

21 (100)

0 (0)

1

0.988

 3

9 (56)

7 (44)

1&2 vs 3

3.7

1.0–14.4

0.058

13 (81)

3 (19)

1&2 vs 3

133,198

0.0–6.45E+ 140

0.941

 4

15 (58)

11 (42)

1&2 vs 4

3.5

1.1–12.5

0.057

19 (73)

7 (27)

1&2 vs 4

120,743

0.0–5.84E+ 140

0.941

 0&1

9 (69)

4 (31)

1

0.698

11 (85)

2 (15)

1

0.372

 2

10 (56)

8 (44)

0&1 vs 2

1.5

0.45–5.0

0.501

13 (72)

5 (28)

0&1 vs 2

3.1

0.36–26.7

0.307

 3

23 (72)

9 (28)

0&1 vs 3

1.0

0.32–3.4

0.947

29 (91)

3 (9)

0&1 vs 3

1.3

0.13–12.2

0.843

 III

9 (64)

5 (36)

1

11 (79)

3 (21)

1

 IVa

33 (67)

16 (33)

0.9

0.37–2.9

0.898

42 (86)

7 (14)

0.5

0.12–2.0

0.328

 High

29 (83)

6 (17)

1

33 (94)

2 (6)

1

 Low

13 (46)

15 (54)

4.0

1.2–10.7

0.008

20 (71)

8 (29)

4.0

0.82–19.2

0.087

 High

32 (89)

4 (11)

1

35 (97)

1 (3)

1

 Low

10 (37)

17 (63)

8.5

3.1–29.6

< 0.001

18 (67)

9 (33)

13.1

1.64–100

0.015

 High

35 (80)

9 (20)

1

42 (95)

2 (5)

1

 Low

7 (37)

12 (63)

3.7

1.5–8.8

0.004

11 (58)

8 (42)

7.6

1.6–37.0

0.011

 Low (≤ 10% of CD3 + TIL)

30 (73)

11 (27)

1

37 (90)

4 (10)

1

 High (> 10% of CD3 + TIL)

12 (55)

10 (46)

1.6

0.7–3.8

0.287

16 (73)

6 (27)

1.8

0.5–7.5

0.376

 Low (<  10% of CD3 + TIL)

16 (62)

10 (38)

1

22 (85)

4 (15)

1

 High (≥ 10% of CD3 + TIL)

24 (71)

10 (29)

0.6

0.2–1.5

0.260

29 (85)

6 (15)

0.60

0.2–1.5

0.260

 Positive (≥ 10%)

32 (71)

13 (29)

1

12 (67)

6 (33)

1

 Negative (<  10%)

10 (56)

8 (44)

1.6

0.7–3.8

0.315

41 (91)

4 (9)

3.1

0.8–11.49

0.100

 Positive (≥ 10%)

22 (69)

10 (31)

1

25 (81)

6 (19)

1

 Negative (<  10%)

20 (65)

11 (35)

1.1

0.4–2.5

0.919

28 (88)

4 (12)

1.3

0.34–4.9

0.702