Fig. 4

Sequential hierarchical clustering/t-SNE profiling of LGG. a. Hierarchical clustering of 534 LGG transcriptomes from TCGA showing four distinct groups (“Dendros’). At the bottom of the panel, the rows of colored bars represent the clusters into which each tumor was grouped following t-SNE analysis with that pathway’s transcripts. b. Kaplan-Meier survival of each Dendro (D1-D4) and the P values for each pair-wise comparison. c. Kaplan-Meier survival of all 534 LGGs based on the t-SNE Clusters to which they were assigned after profiling with Pyrimidine Biosynthesis Pathway transcripts. The number of tumors in each Cluster and the median survival are indicated as are the P values for significant pair-wise comparisons. d. Kaplan-Meier survival of patients from the 149 member Dendro 4 group based on their Pyrimidine Biosynthesis Pathway t-SNE Cluster identities. e. Kaplan-Meier survival for all LGG patients based on the t-SNE Clusters to which they were assigned after profiling with Hippo Pathway transcripts f. Kaplan-Meier survival of patients from the 115 Dendro 2 group based on their Hippo Pathway t-SNE Cluster identities. g. Kaplan-Meier survival of patients from the Dendro 4 group based on their Hippo Pathway t-SNE Cluster identities. h. Kaplan-Meier survival of all LGG patients based on the t-SNE Clusters to which they were assigned after profiling with PI3-kinase Pathway transcripts. i. Kaplan-Meier survival of patients from Dendro 4 based on their PI3-kinase Pathway t-SNE Cluster identities. j. Kaplan-Meier survival of all LGG based on the t-SNE Clusters to which they were assigned after profiling with Wnt Pathway Pathway transcripts. k. Kaplan-Meier survival of patients from Dendro 4 based on their Wnt Pathway t-SNE Cluster identities