Table 2 Association between biological factors and PD-L1 and PD-L2 expression on tumor cells and macrophages
Tumor cell | Intratumoral macrophage | Peritumoral macrophage | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PD-L1 | PD-L1 | PD-L2 | PD-L1 | PD-L2 | |||||||||||
Positive (≥1%) (n=19) | Negative (<1%) (n=51) | p value | High (≥20%) (n=41) | Low (<20%) (n=29) | p value | High (≥25%) (n=41) | Low (<25%) (n=29) | p value | High (≥10%) (n=31) | Low (<10%) (n=11) | p value | High (≥70%) (n=12) | Low (<70%) (n=30) | p value | |
Median age (years) | 67 | 68 | 0.6724 | 66 | 70 | 0.4036 | 70 | 66 | 0.2829 | 69 | 66 | 0.4063 | 70.5 | 66 | 0.3954 |
Sex, male (%) | 11 (57.9) | 27 (52.9) | 0.7114 | 21 (51.2) | 17 (58.6) | 0.5403 | 22 (53.7) | 16 (55.2) | 0.9003 | 14 (45.2) | 5 (45.5) | 0.9866 | 7 (58.3) | 12 (40.0) | 0.2809 |
Median KPS | 80 | 70 | 0.3223 | 80 | 60 | 0.0008 | 70 | 75 | 0.9896 | 80 | 80 | 0.8550 | 80 | 80 | 0.4050 |
Deep-seated lesion (%) | 14 (73.7) | 37 (74.0) | 0.9787 | 30 (73.2) | 21 (75.0) | 0.8651 | 27 (65.9) | 24 (85.1) | 0.0651 | 19 (61.3) | 7 (70.0) | 0.6190 | 9 (75.0) | 17 (58.6) | 0.3218 |
Multiple lesions (%) | 8 (42.1) | 27 (54.0) | 0.3773 | 21 (51.2) | 14 (50.0) | 0.9207 | 22 (53.7) | 13 (46.4) | 0.5553 | 13 (41.9) | 5 (50.0) | 0.6550 | 6 (50.0) | 12 (41.4) | 0.6128 |
LDH elevation (%) | 4 (21.1) | 13 (27.7) | 0.8074 | 12 (31.6) | 5 (17.9) | 0.2077 | 10 (25.0) | 7 (26.9) | 0.8614 | 6 (19.4) | 6 (66.7) | 0.0064 | 2 (16.7) | 10 (35.7) | 0.2283 |
MSKCC score | |||||||||||||||
Class 1 (%) | 3 (15.8) | 4 (8.2) | 0.3861 | 6 (15.0) | 1 (3.6) | 0.0103 | 3 (7.3) | 4 (14.8) | 0.2385 | 3 (9.7) | 1 (10.0) | 0.4664 | 0 (0.0) | 4 (13.8) | 0.3307 |
Class 2 (%) | 9 (47.4) | 27 (55.1) | 25 (62.5) | 11 (39.3) | 25 (61.0) | 11 (40.7) | 19 (61.3) | 8 (80.0) | 8 (66.7) | 19 (65.5) | |||||
Class 3 (%) | 7 (36.8) | 18 (36.7) | 9 (22.5) | 16 (57.1) | 13 (31.7) | 12 (44.4) | 9 (29.0) | 1 (10.0) | 4 (33.3) | 6 (20.7) | |||||