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Fig. 1 | BMC Cancer

Fig. 1

From: Synergistic enhancement of efficacy of platinum drugs with verteporfin in ovarian cancer cells

Fig. 1

Synergistic activity of drugs on OVCA cell lines: IC50 values were calculated using Compusyn software following Chou-Talalay method. These calculations were based on MTT assay which was done in 96-well plates. In each well 5000 cells were seeded. The next day, VP and CDDP/CP/Taxol treatments were initiated and given for 72 h and cell proliferation was measured as per Manufacturer’s instructions (Cell Proliferation Kit). DMSO/sterile PBS /sterile water served as control. n = 6. VP = Verteporfin; CDDP = cisplatin; CP = carboplatin; Taxol = paclitaxel. After determining cell proliferation (MTT assay) of OVCA cells treated with constant ratios of VP and CDDP/CP/Taxol, combination index (CI) values were calculated and represented as heat maps (Microsoft Excel Office 365) where a drug combination is synergistic (green color) if CI < 1.0; additive (yellow color) if CI = 1.0; and antagonistic (red color) if CI > 1.0

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