Table 3 Genotype and allele distribution of MTHFR, XRCC1 and OGG1 polymorphisms
Gene (SNP) | Model | Genotype | Cases n.135 (n. %) | Controls n.112 (n. %) | OR (95% CI) | p | ||
|---|---|---|---|---|---|---|---|---|
MTHFR(rs1801133) Ref. Allele = C Alt. Allele = T | Codominant | C/C | 53 | 39.25 | 31 | 27.68 | 1.00 |  |
C/T | 60 | 44.44 | 62 | 55.36 | 0.57 (0.32–1) | 0.049 | ||
T/T | 22 | 16.30 | 19 | 16.96 | 0.68 (0.32–1.44) | 0.31 | ||
Dominant | C/C | 53 | 39.25 | 31 | 27.68 | 1.00 | Â | |
C/T-T/T | 82 | 60.74 | 81 | 72.32 | 0.59 (0.35–1.02) | 0.06 | ||
Recessive | C/C-C/T | 113 | 83.70 | 93 | 83.03 | 1.00 | Â | |
T/T | 22 | 16.30 | 19 | 16.96 | 0.95 (0.49–1.87) | 0.89 | ||
Overdominant | C/C-T/T | 75 | 55.60 | 50 | 44.64 | 1.00 | Â | |
C/T | 60 | 44.44 | 62 | 55.36 | 0.65 (0.39–1.07) | 0.09 | ||
Allele | C | 166 | 61.48 | 124 | 55.36 | 1.00 | Â | |
T | 104 | 38.52 | 100 | 44.64 | 0.78 (0.54–1.11) | 0.17 | ||
Hardy Weinberg eq. |  | p = 0.47 | p = 0.25 |  |  | |||
MTHFR(rs1801131) Ref. Allele = A Alt. Allele = C | Codominant | A/A | 66 | 48.88 | 56 | 50.00 | 1.00 |  |
A/C | 55 | 40.74 | 49 | 43.75 | 0.95 (0.56–1.61) | 0.86 | ||
C/C | 14 | 10.37 | 7 | 6.25 | 1.7 (0.64–4.5) | 0.28 | ||
Dominant | A/A | 66 | 48.88 | 56 | 50.00 | 1.00 | Â | |
A/C-C/C | 69 | 51.11 | 56 | 50.00 | 1.05 (0.63–1.73) | 0.86 | ||
Recessive | A/A-A/C | 121 | 89.63 | 105 | 93.75 | 1.00 | Â | |
C/C | 14 | 10.37 | 7 | 6.25 | 1.74 (0.68–4.46) | 0.25 | ||
Overdominant | A/A-C/C | 80 | 59.26 | 63 | 56.2 | 1.00 | Â | |
A/C | 55 | 40.74 | 49 | 43.75 | 0.88 (0.53–1.47) | 0.63 | ||
Allele | A | 187 | 69.26 | 168 | 75.00 | 1.00 | Â | |
C | 83 | 30.74 | 63 | 28.12 | 1.18 (0.8–1.74) | 0.39 | ||
Hardy Weinberg eq. |  | p = 0.69 | p = 0.49 |  |  | |||
XRCC1(rs1799782) Ref. Allele = C Alt. Allele = T | Codominant | C/C | 128 | 94.81 | 102 | 91.07 | 1.00 |  |
C/T | 7 | 5.18 | 10 | 8.93 | 0.56 (0.21–1.52) | 0.25 | ||
Allele | C | 263 | 97.40 | 214 | 95.53 | 1.00 | Â | |
T | 7 | 5.18 | 10 | 4.46 | 0.57 (0.21–1.52) | 0.26 | ||
Hardy Weinberg eq. |  | p = 1.00 | p = 1.00 |  |  | |||
XRCC1(rs25487) Ref. Allele = G Alt. Allele = A | Codominant | G/G | 64 | 47.41 | 53 | 47.32 | 1.00 |  |
G/A | 55 | 40.74 | 43 | 38.39 | 1.06 (0.62–1.82) | 0.83 | ||
A/A | 16 | 11.85 | 16 | 14.28 | 0.83 (0.38–1.81) | 0.64 | ||
Dominant | G/G | 64 | 47.40 | 53 | 47.32 | 1.00 | Â | |
G/A-A/A | 71 | 52.59 | 59 | 52.68 | 1 (0.6–1.65) | 0.99 | ||
Recessive | G/G-G/A | 119 | 88.15 | 96 | 85.71 | 1.00 | Â | |
A/A | 16 | 11.85 | 16 | 14.28 | 0.81 (0.38–1.7) | 0.57 | ||
Overdominant | G/G-A/A | 80 | 59.26 | 69 | 61.61 | 1.00 | Â | |
G/A | 55 | 40.74 | 43 | 38.39 | 1.1 (0.66–1.84) | 0.71 | ||
Allele | G | 183 | 67.78 | 149 | 66.52 | 1.00 | Â | |
A | 87 | 64.44 | 75 | 33.48 | 0.94 (0.65–1.38) | 0.77 | ||
Hardy Weinberg eq. |  | p = 0.56 | p = 0.14 |  |  | |||
OGG1(rs1052133) Ref. Allele = C Alt. Allele = G | Codominant | C/C | 87 | 64.44 | 70 | 62.50 | 1.00 |  |
C/G | 46 | 34.07 | 35 | 31.25 | 1.06 (0.62–1.82) | 0.84 | ||
G/G | 2 | 1.48 | 7 | 6.25 | 0.23 (0.05–1.14) | 0.05 | ||
Dominant | C/C | 87 | 64.44 | 70 | 62.50 | 1.00 | Â | |
C/G-G/G | 48 | 35.55 | 42 | 37.50 | 0.92 (0.55–1.55) | 0.75 | ||
Recessive | C/C-C/G | 133 | 98.52 | 105 | 93.75 | 1.00 | Â | |
G/G | 2 | 1.48 | 7 | 6.25 | 0.23 (0.05–1.11) | 0.0465 | ||
Overdominant | C/C-G/G | 89 | 65.92 | 77 | 68.75 | 1.00 | Â | |
C/G | 46 | 34.07 | 35 | 31.25 | 1.14 (0.67–1.94) | 0.64 | ||
Allele | C | 220 | 81.48 | 175 | 78.12 | 1.00 | Â | |
G | 50 | 18.52 | 49 | 21.87 | 0.81 (0.52–1.26) | 0.35 | ||
Hardy Weinberg eq. |  | p = 0.24 | p = 0.4 |  |  | |||