INHBA is a prognostic predictor for patients with colon adenocarcinoma

BMC Cancer

Table 2 Risk factors for overall survival and disease free survival according to Cox proportional hazards regression model

Factors	Subgroup	OS set(n = 420)					DFS set(n = 388)
		Univariate analysis			Multivariate analysis		Univariate analysis				Multivariate analysis
		HR	95%CI	p	HR	95%CI	p	HR	95%CI	p	HR	95%CI	p
Age	<65	1			1			1			1
	65–74	0.99	0.55–1.75	0.960	1.29	0.72–2.32	0.393	0.47	0.27–0.81	0.007	0.50	0.28–0.88	0.016
	≥75	1.86	1.13–3.09	0.016	2.28	1.36–3.83	0.002	0.90	0.60–1.57	0.897	1.23	0.75–2.02	0.421
Gender	Male	1						1
Gender	Female	1.18	0.55–1.31	0.466				0.75	0.49–1.16	0.199
pT	T1	1			1			1			1
	T2	1.62	0.06–5.96	0.676	0.46	0.05–4.48	0.504	1.11	0.13–9.22	0.927	1.12	0.13–9.50	0.917
	T3	2.28	0.32–16.49	0.414	1.16	0.16–8.61	0.886	2.79	0.39–20.16	0.309	1.95	0.26–14.50	0.514
	T4	8.10	1.08–60.79	0.042	3.25	0.42–25.42	0.262	7.68	1.01–58.58	0.049	4.77	0.60–37.82	0.139
pN	N0	1			1			1			1
	N1	1.72	0.98–2.99	0.056	1.25	0.68–2.29	0.467	1.41	0.83–2.40	0.206	0.78	0.44–1.40	0.406
	N2	4.38	2.65–7.21	0.000	2.46	1.36–4.46	0.003	4.22	2.55–6.96	0.000	2.40	1.36–4.24	0.002
pM	M0	1			1			1			1
pM	M1	4.08	2.55–6.53	0.000	2.25	1.29–3.91	0.004	4.69	2.85–7.70	0.000	3.66	2.06–6.53	0.000
INHBA	Low	1			1			1			1
INHBA	High	1.65	1.07–2.55	0.024	1.44	0.93–2.25	0.100	1.94	1.27–2.97	0.002	1.71	1.10–2.65	0.017

ISSN: 1471-2407