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Table 3 The univariables and multi-variables cox regression of clinical parameters and survival outcomes of patients with osteosarcoma

From: A novel risk score model based on eight genes and a nomogram for predicting overall survival of patients with osteosarcoma

Clinical characteristics

TCGA(N = 176)

Uni-variables cox

Multi-variables cox

HR

95%CI

P

HR

95%CI

P

Age(years, mean ± sd)

61.01 ± 15.23

1.018

0.999–1.036

5.19E-02

–

–

–

Gender(Male/Female)

72/104

1.102

0.666–1.827

7.05E-01

–

–

–

Pathologic tumor depth(years, mean ± sd)

6.35 ± 3.69

1.136

0.951–1.227

9.05E-02

–

–

–

Pathologic tumor length(years, mean ± sd)

11.76 ± 7.25

1.061

0.993–1.092

5.91E-02

–

–

–

Pathologic tumor width(years, mean ± sd)

8.78 ± 5.51

1.091

0.940–1.143

2.17E-01

–

–

–

Tumor multifocal(Yes/No/−)

34/132/10

1.685

0.949–2.991

7.13E-02

–

–

–

Tumor recurrence(Yes/No/−)

28/141/7

2.692

1.581–4.585

1.48E-04

1.626

0.914–2.893

9.80E-02

Tumor metastatic(Yes/No/−)

58/118

2.898

1.754–4.789

1.36E-05

1.879

1.079–3.274

2.58E-02

Radiotherapy(Yes/No/−)

64/110/2

0.799

0.474–1.347

3.99E-01

–

–

–

Tumor necrosis(No/Slight/Moderate/Severe/−)

61/35/59/10/11

1.191

0.925–1.530

1.75E-01

–

–

–

RS model status(High/ Low)

88/88

3.13

1.824–5.370

1.28E-05

2.288

1.291–4.057

4.60E-03

Dead(Death/Alive/−)

63/113

–

–

–

–

–

–

Overall survival time(months, mean ± sd)

39.76 ± 32.24

–

–

–

–

–

–

  1. SD Standard deviation, HR Hazard ratio, 95%CI 95% confidence interval,  TCGAThe Cancer Genome Atlas