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Table 2 Location of clusters of dysregulated genes across the canine genome

From: RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors

  BRAFV595E BRAFwt  
Locusa Upb p-val Dnc pval Upb pval Dnc p-val Human orthologd
2:15250–16,500 0 ns 11 8.90E-08 0 ns 10 2.70E-07 10p11.22–23
7:37500–38,750 0 ns 9 1.70E-04 0 ns 11 6.70E-07 1q42.12–13
7:41500–42,500 14 4.30E-06 2 ns 10 3.20E-03 5 ns 1q21.3
7:42750–44,250 13 2.90E-06 4 ns 3 ns 1 ns 1q21.3
7:73250–74,500 0 ns 9 5.20E-08 0 ns 7 7.40E-06 18p11.23
7:73500–75,000 0 ns 7 3.70E-06 0 ns 9 6.80E-10 18p11.23
8:71500–72,500 8 1.50E-03 0 ns 12 2.70E-06 0 ns 14q32.33
9:4750–5750 15 3.50E-07 0 ns 19 4.40E-10 1 ns 17q25.1
9:24000–25,000 14 3.40E-07 1 ns 15 1.30E-07 0 ns 17q21.32
9:47500–49,250 25 1.40E-10 2 ns 33 2.00E-16 4 ns 9q34.3
9:55000–56,000 12 5.00E-05 2 ns 14 4.40E-06 2 ns 9q34.11
11:55500–56,500 0 ns 6 1.10E-03 0 ns 8 3.90E-06 9q22.33
13:1500–2500 7 3.20E-06 0 ns 7 5.50E-06 0 ns 8q22.2
13:36250–38,750 28 2.10E-09 4 ns 45 1.30E-21 1 ns 8q24.3
13:36750–38,250 27 2.90E-10 2 ns 42 8.40E-22 0 ns 8q24.3
13:43000–44,000 10 1.20E-09 0 ns 8 1.20E-06 0 ns 4p12
13:45250–46,250 7 2.90E-05 0 ns 9 2.80E-07 0 ns 4q12
13:57750–58,750 8 2.20E-06 0 ns 2 ns 0 ns 4q13.2
14:250–1250 3 ns 0 ns 10 3.70E-06 0 ns 1q42.13
15:12750–13,750 9 3.40E-06 1 ns 6 2.80E-03 2 ns 1p33
16:35500–37,000 1 ns 3 ns 10 2.20E-07 3 ns 8p22–23.1
17:48250–49,250 4 ns 2 ns 12 1.40E-06 3 ns 2p13.1
18:24750–26,000 8 4.50E-03 1 ns 13 3.30E-06 0 ns 11p15.5
20:49500–50,500 12 2.90E-06 4 ns 10 2.10E-04 5 ns 19p13.2
24:33500–34,750 8 2.20E-06 0 ns 3 9.20E-02 0 ns 20q13.12
25:3000–4000 0 ns 8 3.00E-06 0 ns 4 1.30E-02 13q13.3
38:20500–22,250 7 ns 6 ns 21 2.20E-08 5 ns 1q23.3
  1. aThe positions are given in kilobases. bUp is the number of genes with increased expression. cDn is the number of genes with reduced expression. dHuman ortholog is the orthologous region in human genome build GRCh38/hg38. ns not significant