BMC Cancer

Table 2 Location of clusters of dysregulated genes across the canine genome

From: RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors

	BRAFV595E				BRAFwt
Locus^a	Up^b	p-val	Dn^c	pval	Up^b	pval	Dn^c	p-val	Human ortholog^d
2:15250–16,500	0	ns	11	8.90E-08	0	ns	10	2.70E-07	10p11.22–23
7:37500–38,750	0	ns	9	1.70E-04	0	ns	11	6.70E-07	1q42.12–13
7:41500–42,500	14	4.30E-06	2	ns	10	3.20E-03	5	ns	1q21.3
7:42750–44,250	13	2.90E-06	4	ns	3	ns	1	ns	1q21.3
7:73250–74,500	0	ns	9	5.20E-08	0	ns	7	7.40E-06	18p11.23
7:73500–75,000	0	ns	7	3.70E-06	0	ns	9	6.80E-10	18p11.23
8:71500–72,500	8	1.50E-03	0	ns	12	2.70E-06	0	ns	14q32.33
9:4750–5750	15	3.50E-07	0	ns	19	4.40E-10	1	ns	17q25.1
9:24000–25,000	14	3.40E-07	1	ns	15	1.30E-07	0	ns	17q21.32
9:47500–49,250	25	1.40E-10	2	ns	33	2.00E-16	4	ns	9q34.3
9:55000–56,000	12	5.00E-05	2	ns	14	4.40E-06	2	ns	9q34.11
11:55500–56,500	0	ns	6	1.10E-03	0	ns	8	3.90E-06	9q22.33
13:1500–2500	7	3.20E-06	0	ns	7	5.50E-06	0	ns	8q22.2
13:36250–38,750	28	2.10E-09	4	ns	45	1.30E-21	1	ns	8q24.3
13:36750–38,250	27	2.90E-10	2	ns	42	8.40E-22	0	ns	8q24.3
13:43000–44,000	10	1.20E-09	0	ns	8	1.20E-06	0	ns	4p12
13:45250–46,250	7	2.90E-05	0	ns	9	2.80E-07	0	ns	4q12
13:57750–58,750	8	2.20E-06	0	ns	2	ns	0	ns	4q13.2
14:250–1250	3	ns	0	ns	10	3.70E-06	0	ns	1q42.13
15:12750–13,750	9	3.40E-06	1	ns	6	2.80E-03	2	ns	1p33
16:35500–37,000	1	ns	3	ns	10	2.20E-07	3	ns	8p22–23.1
17:48250–49,250	4	ns	2	ns	12	1.40E-06	3	ns	2p13.1
18:24750–26,000	8	4.50E-03	1	ns	13	3.30E-06	0	ns	11p15.5
20:49500–50,500	12	2.90E-06	4	ns	10	2.10E-04	5	ns	19p13.2
24:33500–34,750	8	2.20E-06	0	ns	3	9.20E-02	0	ns	20q13.12
25:3000–4000	0	ns	8	3.00E-06	0	ns	4	1.30E-02	13q13.3
38:20500–22,250	7	ns	6	ns	21	2.20E-08	5	ns	1q23.3

^aThe positions are given in kilobases. ^bUp is the number of genes with increased expression. ^cDn is the number of genes with reduced expression. ^dHuman ortholog is the orthologous region in human genome build GRCh38/hg38. ns not significant

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