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Table 1 Characteristics of the dogs with bladder cancer from which tumor tissue was collected

From: RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors

Characteristic Outcome
Age Median 10 Years (Range 6–14 years)
Gender 7 Spayed Female
6 Neutered Male
2 Intact Male
Breed 4 Scottish Terriers
3 Mixed Breed
3 Beagles
2 Shetland Sheepdogs, 1 West Highland White Terrier, 1 German Shorthaired Pointer, 1 Miniature Pinscher
TNM Stage at Tissue Collection T2N0M0–5 Dogs
T2N0M1–4 Dogs
T2N1M1–2 Dogs
T3N0M0–1 Dog
T3N1M0–1 Dog
T3N1M1–1 Dog
Prior Therapy 8 Dogs Had Prior Therapy Including: a Cyclooxygenase Inhibitor (7 Dogs), Leukeran (3 Dogs), Vinblastine-Folate Conjugate (2 Dogs), Vinblastine (1 Dog), Carboplatin (1 Dog), 5 Azacitidine (1 Dog), Intravesical Mitomycin C (1 Dog)
Tissue Collection Method 5 tumor tissues were collected by cystoscopy, 10 tumor tissues were collected at necropsy
Mutation Status of Tumor 11 tumors carried the BRAFV595E mutation, 4 tumors had no BRAF mutation