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Fig. 3 | BMC Cancer

Fig. 3

From: RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors

Fig. 3

Positional analysis identifies loci on 15 chromosomes that contain significant numbers of dysregulated genes. The graphs are divided by a) upregulated genes and b) down regulated genes. The x-axis indicates the chromosomes from 1 to X. The y-axis showss the p-value for over-representation of dysregulated genes within a 1 Mb region surrounding each point on the graph. The dotted line indicates the Bonferroni corrected p-value of 0.05. BRAFwt tumors are shown in orange, BRAFV595E tumors are shown in blue. c) The core genes from the up-regulated locus on chr38, syntenic to the human 1q23.3 copy number variant, are overexpressed in canine iUC tumors that do not carry the BRAFV595E mutation. Boxplots display the transcripts per million compared to normal tissues from BRAFwt (orange) and BRAFV595E (blue) tumors

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