Table 2 Age-standardised incidence rates of childhood cancer by ICCC3 site-groups (malignant only), Estonia 1970–2016
Total cases | % | Average annual cases | ASIR/million 1970–1994 | ASIR/million 1995–2016 | APC (%) (1970–2016) | 95% CI | |
|---|---|---|---|---|---|---|---|
All sites | 1628 | 100 | 35 | 122.2 | 138.1 | 0.5 | 0.1–0.9 |
I Leukemias, myeloproliferative diseases, and myelodysplastic diseases | 506 | 31.1 | 11 | 39.5 | 42.1 | 0.2 | −0.7–1.0 |
a. Lymphoid leukemias | 302 | 18.6 | 6 | 20.0 | 31.4 | 2.1 | 0.1–4.0 |
b. Acute myeloid leukemias | 72 | 4.4 | 2 | 4.3 | 7.4 | 1.8 | −1.2–5.0 |
c. Chronic myeloproliferative diseases | 6 | 0.4 | 0 | 0.3 | 0.9 | NC | NC |
d. Myelodysplastic syndrome and other myeloproliferative diseases | 7 | 0.4 | 0 | 0 | 1.6 | NC | NC |
e. Unspecified and other specified leukemias | 119 | 7.3 | 3 | 15.0 | 0.7 | −11.5 | −13.4;-9.6 |
II. Lymphomas and reticuloendothelial neoplasms | 232 | 14.3 | 5 | 16.8 | 17.2 | −0.1 | −1.2–1.0 |
a. Hodgkin lymphomas | 95 | 5.8 | 2 | 7.7 | 5.1 | −1.5 | −3.6–0.7 |
b. Non-Hodgkin lymphomas (except Burkitt lymphoma) | 93 | 5.7 | 2 | 7.4 | 6.0 | −1.0 | −2.8–0.9 |
c. Burkitt lymphoma | 17 | 1.0 | 0 | 0 | 3.3 | 8.8 | 7.4–10.2 |
d. Miscellaneous lymphoreticular neoplasms | 15 | 0.9 | 0 | 0.5 | 2.4 | NC | NC |
e. Unspecified lymphomas | 12 | 0.7 | 0 | 1.2 | 0.4 | −2.0 | −5.4–1.5 |
III. CNS and miscellaneous intracranial and intraspinal neoplasms (malignant only) | 312 | 19.2 | 7 | 22.0 | 27.5 | 0.9 | −0.5–2.3 |
a. Ependymomas and choroid plexus tumors | 43 | 2.6 | 1 | 1.9 | 6.2 | 3.3 | 1.5–5.1 |
b. Astrocytomas | 110 | 6.8 | 2 | 7.7 | 9.0 | 1.1 | −2.7–5.0 |
c. Intracranial and intraspinal embryonal tumors | 78 | 4.8 | 2 | 4.9 | 8.1 | 2.4 | −0.2–5.1 |
d. Other gliomas | 16 | 1.0 | 0 | 0.7 | 2.0 | 3.5 | 1.2–5.8 |
f. Unspecified intracranial and intraspinal neoplasms | 64 | 3.9 | 1 | 6.7 | 1.9 | −5.1 | −8.4;-1.7 |
IV. Neuroblastoma and other peripheral nervous cell tumors | 91 | 5.6 | 2 | 6.3 | 10.4 | 2.3 | 0.0–4.7 |
a. Neuroblastoma and ganglioneuroblastoma | 89 | 5.5 | 2 | 6.1 | 10.4 | 2.5 | 0.3–4.7 |
V. Retinoblastoma | 41 | 2.5 | 1 | 3.4 | 4.0 | −0.2 | −3.4–3.2 |
VI. Renal tumors | 132 | 8.1 | 3 | 12.6 | 9.1 | −0.8 | − 3.0–1.4 |
a. Nephroblastoma and other nonepithelial renal tumors | 127 | 7.8 | 3 | 11.9 | 9.1 | −0.6 | −2.7–1.5 |
VII. Hepatic tumors | 26 | 1.6 | 1 | 1.9 | 2.9 | 1.1 | −1.7–4.1 |
a. Hepatoblastoma | 18 | 1.1 | 0 | 1.0 | 2.7 | NC | NC |
VIII. Malignant bone tumors | 71 | 4.4 | 2 | 4.6 | 5.5 | 0.3 | −2.6–3.2 |
a. Osteosarcomas | 27 | 1.7 | 1 | 1.7 | 2.2 | −0.6 | −3.6–2.5 |
c. Ewing tumor and related sarcomas of bone | 25 | 1.5 | 1 | 1.1 | 2.6 | 3.2 | −0.6–7.1 |
e. Unspecified malignant bone tumors | 12 | 0.7 | 0 | 1.1 | 0.3 | −3.3 | −4.8;-1.7 |
IX. Soft tissue and other extraosseous sarcomas | 81 | 5.0 | 2 | 5.8 | 7.2 | 1.3 | −0.0–2.6 |
a. Rhabdomyosarcomas | 32 | 2.0 | 1 | 1.8 | 3.9 | 3.0 | −0.5–6.7 |
b. Fibrosarcomas. peripheral nerve sheath tumors. and other fibrous neoplasms | 12 | 0.7 | 0 | 1.1 | 0.6 | 0.4 | −2.1–2.9 |
d. Other specified soft tissue sarcomas | 26 | 1.6 | 1 | 1.6 | 2.5 | 1.5 | −1.4–4.4 |
e. Unspecified soft tissue sarcomas | 10 | 0.6 | 0 | 1.2 | 0.3 | −2.0 | −4.9–1.0 |
X. Germ cell tumors, trophoblastic tumors, and neoplasms of gonads | 75 | 4.6 | 2 | 4.7 | 8.3 | 2.5 | 0.2–4.9 |
a. Intracranial and intraspinal germ cell tumors | 8 | 0.5 | 0 | 0.1 | 1.3 | 5.1 | 2.1–8.1 |
b. Malignant extracranial and extragonadal germ cell tumors | 34 | 2.1 | 1 | 2.0 | 4.6 | 3.4 | 1.1–5.7 |
c. Malignant gonadal germ cell tumors | 26 | 1.6 | 1 | 1.9 | 2.2 | 0.7 | −2.2–3.7 |
XI. Other malignant epithelial neoplasms and malignant melanomas | 41 | 2.5 | 1 | 2.3 | 3.5 | 1.4 | −0.8–3.7 |
b. Thyroid carcinomas | 10 | 0.6 | 0 | 0.2 | 1.3 | 3.7 | −0.9–8.7 |
d. Malignant melanomas | 12 | 0.7 | 0 | 0.8 | 0.8 | −0.2 | −2.8–2.5 |
f. Other and unspecified carcinomas | 12 | 0.7 | 0 | 0.9 | 0.8 | 0.3 | −2.2–2.8 |
XII. Other and unspecified malignant neoplasms | 20 | 1.2 | 0 | 2.3 | 0.6 | −2.4 | −3.9;-0.9 |
b. Other unspecified malignant tumors | 17 | 1.0 | 0 | 2.0 | 0.4 | −3.4 | −4.5;-2.3 |