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Table 2 Unadjusted and adjusted determinants of chemotherapy initiation within 30 days of Kaposi’s sarcoma (KS) diagnosis among HIV-infected patients newly diagnosed with KS between 2009 and 2012 in a large community-based primary care network in Kenya

From: Real-world use of chemotherapy for Kaposi’s sarcoma in a large community-based HIV primary care system in Kenya

 

Unadjusted

Adjusted Model 1a

Adjusted Model 2a

Characteristic

Risk Ratio

(95% CI)

P value

Risk Ratio

(95% CI)

P value

Risk Ratio (95% CI)

P value

Age, years

  ≤ 30

Ref.

 

Ref.

 

Ref.

 

 30–34

1.02 (0.72–1.45)

0.908

1.04 (0.64–1.68)

0.872

1.00 (0.60–1.66)

0.997

 35–39

0.66 (0.42–1.03)

0.068

0.72 (0.41–1.25)

0.242

0.62 (0.34–1.13)

0.119

  ≥ 40

0.81 (0.55–1.19)

0.285

0.85 (0.51–1.39)

0.511

0.83 (0.49–1.41)

0.489

Gender

 Women

Ref.

 

Ref.

 

Ref.

 

 Men

1.10 (0.82–1.49)

0.520

1.10 (0.75–1.62)

0.623

1.04 (0.69–1.57)

0.838

Chemotherapy indications

 1 chemotherapy indication

Ref.

 

Ref.

 

Ref.

 

 2 chemotherapy indications

1.75 (1.26–2.44)

0.001

1.82 (1.19–2.79)

0.006

1.86 (1.20–2.87)

0.005

  ≥ 3 chemotherapy indications

2.18 (1.58–3.01)

< 0.001

2.30 (1.46–3.60)

< 0.001

2.43 (1.51–3.91)

< 0.001

CD4+ T cells, count/μl

  > 350

Ref.

 

Ref.

 

Ref.

 

 201–350

1.55 (0.93–2.59)

0.091

1.61 (0.85–3.06)

0.143

1.54 (0.80–2.98)

0.200

 51–200

1.65 (1.03–2.63)

0.036

1.74 (0.97–3.11)

0.063

1.86 (1.03–3.37)

0.040

  < 50

1.11 (0.60–2.07)

0.731

1.04 (0.49–2.20)

0.913

1.04 (0.49–2.23)

0.909

 CD4 unknown

1.06 (0.65–1.74)

0.720

1.07 (0.60–1.92)

0.820

1.03 (0.56–1.89)

0.921

Education

 None

Ref.

   

Ref.

 

 Primary

1.00 (0.55–1.80)

0.990

  

0.85 (0.39–1.85)

0.689

 Secondary

1.18 (0.64–2.19)

0.590

  

1.09 (0.48–2.44)

0.842

 Tertiary

1.31 (0.56–3.07)

0.540

  

1.20 (0.38–3.82)

0.760

Travel time to clinic

  < 30 min

Ref.

   

Ref.

 

 30–59 min

1.05 (0.67–1.65)

0.837

  

1.06 (0.60–1.87)

0.835

 1–2 h

1.22 (0.78–1.91)

0.387

  

1.18 0.67–2.07)

0.567

  > 2 h

1.42 (0.91–2.20)

0.119

  

1.37 (0.76–2.45)

0.295

Water piped into home

 No

Ref.

   

Ref.

 

 Yes

1.11 (0.74–1.68)

0.604

  

1.14 (0.65–1.97)

0.652

  1. aall variables adjusted for all other variables in column