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Table 1 Dose equivalents, survival and toxicity of CED-TMZ and single intratumoral bolus injection of TMZ in mice bearing GL261 gliomas

From: Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

TreatmentTotal administered dosePump dose equivalentCure rateToxicity
(μg)n(%)p valuen(%)
CED-TMZ 3- days pump1802045< 0.0001
Single intratumoral bolus injection17563 days16NS2/633
60122 days250.02791/128
12.5121 day25NS
2.561 h0NS
Non-treated80