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Table 1 Dose equivalents, survival and toxicity of CED-TMZ and single intratumoral bolus injection of TMZ in mice bearing GL261 gliomas

From: Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

Treatment

Total administered dose

Pump dose equivalent

Cure rate

Toxicity

(μg)

n

(%)

p value

n

(%)

CED-TMZ 3- days pump

180

20

45

< 0.0001

Single intratumoral bolus injection

175

6

3 days

16

NS

2/6

33

60

12

2 days

25

0.0279

1/12

8

12.5

12

1 day

25

NS

2.5

6

1 h

0

NS

Non-treated

8

0