Fig. 2From: Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomasKaplan Meyer survival curve displays the therapeutic effect of intratumoral bolus of TMZ administered at day 7 in C57BL/6 mice bearing the orthotopically syngeneic GL261 glioma. Log-rank test analysis showed significantly prolonged median survival in mice treated with 60 μg of TMZ (n = 12) compared with non-treated (n = 8). TMZ 60 μg injection vs. non-treated (*p = 0.0279). Survival was monitored for 100 days. Toxicity was present immediately after the injection in both highest doses 175 μg (2/6; 33%) and 60 μg (1/12; 8%) (pointed area)Back to article page