Table 1 Associations between HIF-1α, Vimentin and clinico-pathological characteristics in HCC
Variant | No. of patients | HIF-1α | p-value | Vimentin | p-value | ||
|---|---|---|---|---|---|---|---|
Low(%) | High(%) | Low(%) | High(%) | ||||
Cases | 77 | 34(44.2) | 43(55.8) | 27(35.1) | 50(64.9) | ||
Age (years) | |||||||
≤ 60 | 62 | 28(45.2) | 34(54.8) | 0.718a | 21(33.9) | 41(66.1) | 0.655a |
> 60 | 15 | 6(40.0) | 9(60.0) | 6(40.0) | 9(60.0) | ||
Gender | |||||||
Male | 63 | 27(42.9) | 36(57.1) | 0.626a | 19(30.2) | 44(69.8) | 0.056a |
Female | 14 | 7(50.0) | 7(50.0) | 8(57.1) | 6(42.9) | ||
Tumor size (cm) | |||||||
≤ 3 | 35 | 18(51.4) | 17(48.6) | 0.241a | 15(42.9) | 20(57.1) | 0.191a |
> 3 | 42 | 16(38.1) | 26(61.9) | 12(28.6) | 30(71.4) | ||
Clinical stage | |||||||
I/II | 42 | 23(54.8) | 19(45.2) | 0.065a | 20(47.6) | 22(52.4) | 0.011a* |
III/IV | 35 | 11(31.4) | 24(68.6) | 7(20.0) | 28(80.0) | ||
Invasion depth | |||||||
T1 + T2 | 40 | 16(40.0) | 24(60.0) | 0.445a | 17(42.5) | 23(57.5) | 0.155a |
T3 + T4 | 37 | 18(48.6) | 19(51.4) | 10(27.0) | 27(73.0) | ||
Lymph nodes metastasis | |||||||
N0 (negative) | 46 | 25(54.3) | 21(45.7) | 0.028a* | 22(47.8) | 24(52.2) | 0.016a* |
N1 (positive) | 31 | 9(29.0) | 22(71.0) | 7(21.2) | 24(78.8) | ||
Distant metastasis | |||||||
M0 (absent) | 72 | 33(45.8) | 39(54.2) | 0.510b | 25(34.7) | 47(65.3) | 0.811b |
M1 (present) | 5 | 1(20.0) | 4(80.0) | 2(40.0) | 3(60.0) | ||
VM | |||||||
Negative | 50 | 27(54.0) | 23(46.0) | 0.018 a* | 22(44.0) | 28(56.0) | 0.025a* |
Positive | 27 | 7(25.9) | 20(74.1) | 5(18.5) | 22(81.5) | ||