Fig. 5

Treatment strategies for partial-responders. The distribution in responses of 30 patients were sketched for each treatment strategy using 30 sets of good fits of calibrated parameters for partial responders (solid line represents median while dotted lines enclose 90% of the predictions). See a sample set of parameter values used in the plots in Table 2. a. Effects of increased interleukin-12 (IL-12) dose from 1 time (1X, control) to 3, 5, 10 times (3X, 5X, 10X, respectively). b. Effects of moderately increased OXP dose from 1 time (1X, control) to 2, 4, 6 times (2X, 4X, 6X, respectively). c. Effects of aggressively increased OXP dose from 1 time (1X, control) to 10, 100, 200 times (10X, 100X, 200X, respectively). d. Effects of increased number of treatment cycles from 3 cycles to 4, 5, and 6 cycles