Skip to main content
Fig. 2 | BMC Cancer

Fig. 2

From: An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

Fig. 2

Quantified Mif-induced IL-12 expression. Simulated IL-12 expression as a function of time and Mif (the green curves) was calibrated to (mean + s.d.) experimental data reported in Fig. 1a and b in [6] in (a) and (b), respectively.The HC-Ad/RUmIL-12 vector was administered at 2.5* 108 IU/mouse in C57BL/6 mice by intrahepatic injection. A set of 8 mice received an adjusted protocol (red circles, n =8) that consisted of 125 μg/kg Mifepristone days 1-2; 250 μg/kg days 3-5; 500 μg/kg days 5-7 and 1000 μg/kg days 9-11 in (a) and a single dose of Mifepristone (125; 250; 1000; 2000 or 4000 μg/kg) was administered intraperitoneally to different groups of animals (n =5) after 2 weeks in (b). The concentration of IL-12 in serum was determined 10 h after induction at the indicated days. Experimental data in error bars represent mean + s.d

Back to article page