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Fig. 2 | BMC Cancer

Fig. 2

From: Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

Fig. 2

NLRP3, caspase-1, GSDMD and IL-1β are highly expressed in endometrial cancer tissues using IHC. A total of 15 endometrioid carcinoma tissues (low-grade G1, middle-grade G2, and high-grade G3), three atypical hyperplasia endometrial tissues, and six benign endometrial tissues are depicted. Cytoplasmic immunostaining of NLRP3, caspase-1, GSDMD and IL-1β in endometrial cancer tissues and secretory endometrium (magnification, 200×). Moderate -to-strong expression of NLRP3, caspase-1, and GSDMD were observed in endometrial carcinomas and atypical hyperplastic endometrial tissues, while negative or weak expression of these pyroptotic proteins were observed in benign endometrial tissues. N: negative or weak expression; P: moderate -to-strong expression; Significantly difference was observed in key pyroptotic protein caspase-1 and GSDMD. * P < 0.05, # P > 0.05 compared with the control group (See Additional file 4)

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