Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study

Table 5 Association between different HER2, UGT1A4, and UGT2B7 SNP genotypes and the Clinico-pathological attributes of breast cancer (BC)

Clinical attributes of BC	HER2	UGT1A4			UGT2B7
Clinical attributes of BC	rs1058808 GG vs GC vs CC	rs12468274 TT vs CT	rs2011425 TT vs TG	rs6755571 CC vs CA vs AA	rs28365062 AA vs AG vs GG	rs4348159 CC vs CT vs TT
Age at BC diagnosis ^b	0.457	0.443	0.677	0.958	0.249	0.242
Age at first pregnancy ^b	0.712	0.363	0.280	0.593	0.416	0.258
Age at menarche ^b	0.352	0.733	0.632	0.610	0.303	0.301
Age at menopause ^b	0.369	0.198	0.257	0.802	0.817	0.477
Allergy ^a	0.393	0.001	0.901	0.820	0.296	0.363
Body mass index ^b	0.373	0.264	0.177	0.729	0.806	0.796
Breastfeeding status ^a	0.107	0.424	0.556	0.058	0.839	0.726
Co-morbidity ^a	0.137^a	0.2802	0.884	0.936	0.895	0.889
Family history ^a	0.46	0.882	0.337	0.221	0.418	0.686
Smoking ^a	0.275	0.380	0.150	0.273	0.667	0.403
Pathological attributes of BC
Axillary lymph nodes^a	0.645	0.994	0.607	0.447	0.967	0.451
Estrogen receptor^a	0.051	0.555	0.583	0.705	0.798	0.121
HER2^a	0.054	0.223	0.295	0.968	0.223	0.567
Histology classification ^a	0.786	0.916	0.201	0.535	0. 820	0.927
IHC profile^a	0.252	0.472	0.409	0.918	0.472	0.826
Lymph node involvement ^a	0.875	0.368	0.658	0.386	0.769	0.317
Progesterone receptor ^a	0.010	0. 770	0.109	0.422	0.919	0.496
Tumor differentiation^a	0.288	0.426	0.690	0.373	0.373	0.855
Tumor size ^b	0.013	0.323	0.002	0.232	0.359	0.941
Tumor stage ^a	0.580	0.712	0.347	0.322	0.675	0.788

^aPearson’s chi-squared test was used to determine genotype-phenotype association
^bAnalysis of variance (ANOVA) test was used to determine genotype-phenotype association

ISSN: 1471-2407