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Table 2 Association of the investigated ESR1, ESR2, HER2, UGT1A4, and UGT2B7 SNPs and breast cancer (BC)

From: Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study

GeneSNP IDAllelic and Genotypic Frequencies in Cases and Controls
Allele/GenotypeCases
(n = 218)
Controls
(n = 219)
P-valueChi-square
ESR1rs2234693C222(0.51)221(0.51)0.9430.005
T216(0.49)213(0.49)
CC60 (27.4)48 (22.1)0.0695.328
TC102 (46.6)125 (57.6)
TT57 (26)44 (20.3)
rs9340799A231(0.53)234(0.54)0.7820.076
G205(0.47)200 (0.46)
AA64 (29.4)54 (24.9)0.0675.383
AG103 (47.2)126 (58.1)
GG51 (23.4)37 (17.1)
rs3020410C399(0.9)399(0.92)0.3870.748
A43(0.1)35(0.08)
CC181 (81.9)184 (84.8)0.6980.718
CA37 (16.7)31 (14.3)
AA3 (1.4)2 (0.9)
rs3798577T258(0.59)224(0.52)0.0245.033
C178(0.41)210(0.48)
TT80 (36.7)56 (25.8)0.0476.076
TC98 (45)112 (51.6)
CC40 (18.4)49 (22.6)
ESR2rs1256049C434(0.98)425(0.98)0.7770.08
T8(0.02)9(0.02)
CC213 (96.4)208 (95.8)0.7740.082
CT8 (3.6)9 (4.2)
HER2rs1058808G300(0.68)296(0.68)N/AN/A
C140(0.32)138(0.32)
GG101 (45.9)105 (48.4)0.5031.372
GC98 (44.5)86 (39.6)
CC21 (9.6)26 (12)
UGT1A4rs12468274T400(0.92)402(0.93)0.6270.236
C36 (0.08)32(0.07)
TT182 (83.5)185 (85.2)0.6110.258
CT36 (16.5)32 (14.8)
rs2011425T399(0.91)392(0.91)0.9740.001
G39(0.09)38 (0.09)
TT180 (82.2)177 (82.3)0.9740.001
TG39 (17.8)38 (17.7)
rs6755571C416(0.94)413(0.95)0.6940.154
A26(0.06)23(0.05)
CC196 (88.7)197 (90.4)0.6380.897
CA24 (10.9)19 (8.7)
AA1 (0.4)2 (0.9)
UGT2B7rs28365062A371(0.84)362(0.83)0.6050.267
G69 (0.16)74(0.17)
AA159 (72.3)152 (69.7)0.8290.374
GA53 (24.1)58 (26.6)
GG8 (3.6)8 (3.7)
rs4348159C369(0.84)361(0.83)0.7850.074
T71(0.16)73(0.17)
CC158 (71.8%)152 (70)0.8600.3
TC53 (24.1%)57 (26.3)
TT9 (4.1%)8 (3.7)
  1. P-Value < 0.05 was considered as significant