Table 4 Multivariate analysis of indicators for survival in CRC patients in in our own cohort
From: Downregulated SPINK4 is associated with poor survival in colorectal cancer
Variable | Group | HR | (95% CI) | Â | P value |
|---|---|---|---|---|---|
Overall survival | |||||
 Univariate analysis | |||||
  Gender | (female vs. male) | 0.583 | 0.275 | 1.236 | 0.159 |
  Age | (per year) | 1.037 | 1.004 | 1.070 | 0.026 |
  BMI | (per kg/m2) | 0.963 | 0.862 | 1.074 | 0.496 |
  TNM stage | (per stage) | 3.135 | 1.936 | 5.078 | 0.000 |
  Tumor size | (per cm) | 1.091 | 0.925 | 1.287 | 0.300 |
  Pretreatment CEA level | (per ng/mL) | 1.014 | 1.002 | 1.027 | 0.024 |
  Pretreatment CA199 level | (per U/ml) | 1.004 | 1.001 | 1.007 | 0.004 |
  Histological type | (mucinous adenocarcinoma vs. adenocarcinoma) | 1.994 | 0.693 | 5.739 | 0.201 |
  Perineural invasion | (yes vs. No) | 3.796 | 1.133 | 12.712 | 0.031 |
  Venus invasion | (yes vs. No) | 1.398 | 0.533 | 3.669 | 0.496 |
  Tumor location |  | 0.981 | 0.568 | 1.696 | 0.946 |
  Differentiation | (well to moderately differentiated vs. poorly differentiated) | 1.435 | 0.341 | 6.043 | 0.622 |
  SPINK4 expression | (high vs. low) | 0.289 | 0.100 | 0.832 | 0.021 |
 Multivariate analysis | |||||
  Age | (per year) | 1.034 | 1.003 | 1.066 | 0.031 |
  TNM stage | (per stage) | 3.093 | 1.873 | 5.109 | 0.000 |
  SPINK4 expression | (high vs. low) | 0.299 | 0.103 | 0.872 | 0.027 |
Disease-free survival | |||||
 Univariate analysis | |||||
  Gender | (female vs. male) | 0.616 | 0.298 | 1.273 | 0.191 |
  Age | (per year) | 1.034 | 1.003 | 1.066 | 0.033 |
  BMI | (per kg/m2) | 0.962 | 0.867 | 1.069 | 0.474 |
  TNM stage | (per stage) | 3.104 | 1.943 | 4.957 | 0.000 |
  Tumor size | (per cm) | 1.099 | 0.936 | 1.291 | 0.247 |
  Pretreatment CEA level | (per ng/mL) | 1.012 | 1.000 | 1.024 | 0.059 |
  Pretreatment CA199 level | (per U/ml) | 1.004 | 1.001 | 1.007 | 0.003 |
  Histological type | (mucinous adenocarcinoma vs. adenocarcinoma) | 1.916 | 0.670 | 5.482 | 0.225 |
  Perineural invasion | (yes vs. No) | 2.918 | 0.873 | 9.757 | 0.082 |
  Venus invasion | (yes vs. No) | 1.534 | 0.629 | 3.741 | 0.347 |
  Tumor location |  | 1.051 | 0.617 | 1.792 | 0.855 |
  Differentiation | (well to moderately differentiated vs. poorly differentiated) | 1.424 | 0.340 | 5.975 | 0.629 |
  SPINK4 expression | (high vs. low) | 0.261 | 0.091 | 0.747 | 0.012 |
 Multivariate analysis | |||||
  TNM stage | (per stage) | 3.298 | 1.986 | 5.475 | 0.000 |
  SPINK4 expression | (high vs. low) | 0.264 | 0.091 | 0.766 | 0.014 |