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Table 3 Multivariate analysis of indicators for overall survival in CRC patients in GSE24551, GSE39582 and TCGA database

From: Downregulated SPINK4 is associated with poor survival in colorectal cancer

Datasets

Variable

Group

HR

(95% CI)

 

P value

GSE24551 dataset

Univariate analysis

     

 TNM stage

(III vs. II)

1.966

1.190

3.246

0.008

 Microsatellite status

(MSI-H vs. MSS, MSI-L)

0.246

0.077

0.786

0.018

 SPINK4 expression

(high vs. low)

0.413

0.188

0.906

0.027

Multivariate analysis

     

 TNM stage

(III vs. II)

1.977

1.181

3.310

0.010

 Microsatellite status

(MSI-H vs. MSS, MSI-L)

0.231

0.072

0.738

0.013

 SPINK4 expression

(high vs. low)

0.462

0.210

1.018

0.056

GSE39582 dataset

Univariate analysis

     

 Gender

(female vs. male)

0.773

0.569

1.051

0.100

 Age

(per year)

1.024

1.011

1.037

0.000

 TNM stage

(III-IV vs. I-II)

2.033

1.644

2.513

0.000

 MMR status

(dMMR vs. pMMR)

0.808

0.488

1.340

0.410

 TP53 status

(MT vs. WT)

1.290

0.884

1.883

0.187

 KRAS status

(MT vs. WT)

1.347

0.989

1.834

0.059

 BRAF status

(MT vs. WT)

1.162

0.681

1.982

0.582

 SPINK4 expression

(high vs. low)

0.662

0.464

0.944

0.023

Multivariate analysis

     

 Age

(per year)

1.025

1.012

1.039

0.000

 TNM stage

(III-IV vs. I-II)

1.921

1.406

2.625

0.000

 KRAS status

(MT vs. WT)

1.365

1.001

1.861

0.050

 SPINK4 expression

(high vs. low)

0.636

0.444

0.911

0.014

TCGA dataset

Univariate analysis

     

 Gender

(female vs. male)

0.884

0.593

1.318

0.545

 Age

(per year)

1.018

1.002

1.035

0.030

 TNM stage

(III-IV vs. I-II)

3.002

1.979

4.554

0.000

 KRAS status

(MT vs. WT)

1.416

0.610

3.288

0.418

 Tumor deposits

(yes vs. No)

1.752

0.854

3.594

0.126

 Perineural invasion

(yes vs. No)

1.938

0.981

3.826

0.057

 Venus invasion

(yes vs. No)

2.566

1.658

3.970

0.000

 Pretreatment CEA level

(per ng/mL)

1.001

1.001

1.002

0.000

 Lymphatic invasion

(yes vs. No)

2.140

1.393

3.287

0.001

 Histological type

(mucinous adenocarcinoma vs. adenocarcinoma)

1.374

0.802

2.352

0.247

 SPINK4 expression

(high vs. low)

0.479

0.321

0.714

0.000

Multivariate analysis

     

 Age

(per year)

1.040

1.003

1.078

0.034

 TNM stage

(III-IV vs. I-II)

3.750

1.323

10.635

0.013

 Perineural invasion

(yes vs. No)

2.359

0.864

6.445

0.094

 Venous invasion

(yes vs. No)

2.773

1.066

7.217

0.037

 SPINK4 expression

(high vs. low)

0.301

0.116

0.785

0.014

  1. MSS, microsatellite Stable; MSI-L, microsatellite instability-low; MSI-H, microsatellite instability-high; WT, wide type; MT, mutation type