From: Downregulated SPINK4 is associated with poor survival in colorectal cancer
 | Low expression | High expression | P value | ||
---|---|---|---|---|---|
Gender | 0.405 | ||||
 Male | 28 | (50.0) | 15 | (60.0) |  |
 Female | 28 | (50.0) | 10 | (40.0) |  |
Age (years) | 63.3 ± 12.4 |  | 64.1 ± 12.1 |  | 0.809 |
BMI (kg/m2) | 22.0 ± 3.4 |  | 23.9 ± 2.5 |  | 0.031 |
TNM stage | 0.025 | ||||
 I-II | 23 | (41.1) | 17 | (68.0) |  |
 III-IV | 33 | (58.9) | 8 | (32.0) |  |
Tumor size (cm) | 5.0 ± 2.0 |  | 4.1 ± 1.6 |  | 0.075 |
Histological type | 0.366 | ||||
 Adenocarcinoma | 53 | (94.6) | 22 | (88.0) |  |
 Mucinous adenocarcinoma | 3 | (5.4) | 3 | (12.0) | 0.306 |
Pretreatment CEA level (ng/mL) | 11.1 ± 22.1 |  | 11.4 ± 22.1 |  | 0.953 |
Pretreatment CA199 level (U/ml) | 32.8 ± 75.3 |  | 17.5 ± 17.9 |  | 0.319 |
Perineural invasion | 4 | (7.1) | 0 | (0.0) | Â |
Venus invasion | 8 | (14.3) | 3 | (12.0) | 1.000 |
Tumor location | 0.874 | ||||
 Left colon | 5 | (8.9) | 3 | (12.0) |  |
 Right colon | 19 | (33.9) | 9 | (36.0) |  |
 Rectum | 32 | (57.1) | 13 | (52.0) |  |
Tumor grade | 0.583 | ||||
 Well to moderately differentiated | 54 | (96.4) | 23 | (92.0) |  |
 Poorly differentiated | 2 | (3.6) | 2 | (8.0) |  |