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Table 1 Subcellular localizations of proteins in breast cancers. n = Number of patients. Localization of Bag-1, Akt, phospho-Akt Ser473, Bad, and phospho-Bad (Ser136 andSer112) proteins were graded for patients with ER + PR + Her2-, ER + PR + Her2+, ER-PR-Her2+ and ER-PR-Her2- subtypes

From: Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer

Tumor Subtypes

Nuclear

Cytoplasmic

Nuclear and Cytoplasmic

ER + PR + HER2-(n = 9)

 Bag-1

–

2

7

 Akt

–

7

2

 P-Akt S473

–

9

–

 P-Bad S112

–

9

–

 P-Bad S136

4

–

5

 Bad

–

5

–

ER + PR + HER2+(n = 6)

 Bag-1

–

–

6

 Akt

–

5

1

 P-Akt S473

–

6

–

 P-Bad S112

–

5

–

 P-Bad S136

5

–

1

 Bad

–

5

–

ER-PR-HER2+(n = 5)

 Bag-1

–

5

–

 Akt

–

5

–

 P-Akt S473

–

5

–

 P-Bad S112

–

5

–

 P-Bad S136

3

–

2

 Bad

–

2

–

ER-PR-HER2-(n = 5)

 Bag-1

–

2

1

 Akt

–

4

–

 P-Akt S473

–

4

–

 P-Bad S112

–

3

–

 P-Bad S136

4

–

–

 Bad

–

–

–