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Table 1 Up-regulation of the identified genes independently associate with poor survival in ovarian cancer patients

From: Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer

Gene

OS

Adjusted OS

PFS

Adjusted PFS

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

POSTN

1.16 (1.09, 1.22)

4.56E-07

1.09 (1.02, 1.16)

0.0137

1.14 (1.06, 1.22)

0.0003

1.09 (1.01, 1.17)

0.0349

LUM

1.18 (1.12, 1.25)

2.67E-09

1.10 (1.03, 1.18)

0.0039

1.17 (1.10, 1.26)

6.17E-06

1.12 (1.04, 1.21)

0.0043

THBS2

1.22 (1.15, 1.30)

3.59E-10

1.13 (1.05, 1.21)

0.0008

1.21 (1.12, 1.29)

2.77E-07

1.13 (1.05, 1.23)

0.0023

COL3A1

1.18 (1.12, 1.25)

1.46E-08

1.10 (1.03, 1.18)

0.0053

1.20 (1.12, 1.29)

2.05E-07

1.14 (1.05, 1.23)

0.0010

COL5A1

1.20 (1.14, 1.27)

6.31E-11

1.13 (1.05, 1.21)

0.0005

1.17 (1.09, 1.25)

8.38E-06

1.11 (1.03, 1.20)

0.0091

COL5A2

1.20 (1.14, 1.27)

3.15E-11

1.12 (1.04, 1.19)

0.0015

1.18 (1.10, 1.27)

1.70E-06

1.12 (1.03, 1.21)

0.0047

FAP

1.20 (1.14, 1.27)

2.52E-11

1.13 (1.06, 1.21)

0.0003

1.18 (1.10, 1.26)

1.61E-06

1.13 (1.05, 1.22)

0.0019

FBN1

1.19 (1.12, 1.25)

2.93E-09

1.12 (1.05, 1.19)

0.0010

1.13 (1.05, 1.23)

1.71E-06

1.18 (1.10, 1.27)

0.0013

  1. Adjusted OS/adjusted PFS: results were adjusted for tumor stage and debulking status