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Fig. 4 | BMC Cancer

Fig. 4

From: Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer

Fig. 4

The activation of CAFs contributes to the overexpression of the LMGS in lymphovascular metastasis. a-c GSEA plots showed that pathways representative of CAF activation were significantly enriched in LVSI-positive samples, as well as in stromal profiles with high levels of the LMGS in the dataset GSE40595 d-f. The Pearson’s correlation analysis between the expression of the identified genes and CAF-specific markers was conducted based on the transcriptome profiles of ovarian cancer stroma in dataset g GSE115635 and h GSE40595. i All the identified genes were significantly unregulated in the ovarian fibroblasts NOF151-hTERT treated with either TGF-β1 or TGF-β2 compared to controls, according to the expression profiles in the dataset GSE40266

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BMC Cancer

ISSN: 1471-2407

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