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Fig. 2 | BMC Cancer

Fig. 2

From: Microbial antigens-loaded myeloma cells enhance Th2 cell proliferation and myeloma clonogenicity via Th2–myeloma cell interaction

Fig. 2

Cytokines levels determined by ELISA assay. IL-4, IFN- γ, and IL-12 are mainly secreted by Th2 cells, Th1 cells, and CD8 + T (CTL) cells, respectively, while Th2 cells cannot secrete IL-12 and IFN-γ, Th1 cells cannot secrete IL-12 and IL-4, and CTL cells cannot secrete IL-4 and IFN-γ. The levels of IL-4 and IFN-γ were not increased in the untreated-RPMI8266 group, but the levels did increase in treated-RPMI8266 cells group in a dose-dependent manner; * p < 0.05. (A,C) The increased IL-4 and IFN-γ levels were markedly repressed in the treated-RPMI8266 + anti-HLA-DR group but not in the anti-MHC-I and treated-RPMI8266 + control IgG2b groups; # p < 0.05. (B) The levels of IL-12 were significantly increased in every group except in the treated-RPMI8266 + anti-MHC-I group in a dose-dependent manner; * p < 0.05. The increasing of IL-12 level could be repressed in the treated-RPMI8266 + anti-MHC-I group but not in the treated-RPMI8266 + anti-HLA-DR and treated-RPMI8266 + control IgG2b groups; # p < 0.05

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