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Fig. 4 | BMC Cancer

Fig. 4

From: Focused screening reveals functional effects of microRNAs differentially expressed in colorectal cancer

Fig. 4

Differential gene expression in HCT116 treated with miR-101-3p. HCT116 cells were transfected with control miRNA (PMC, n = 3) or miR-101-3p (n = 3) and submitted to microarray for differential gene expression. (a) Volcano plot showing downregulated (red) and upregulated (green) transcripts as a function of fold-change and P-value after 3 days of treatment. (b) Venn diagram showing number and relative percentages of shared and exclusive transcripts among those experimentally identified by microarray analysis (downregulated), predicted by TargetScan or functionally validated targets identified in the miRTarBase. (c) All 47 high confidence targets predicted by TargetScan and identified as validated targets by miRTarBase that were downregulated by miR-101-3p in our microarray analysis

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