Fig. 2

MRI of a typical case before and after treatment. a Evidence of a Gadolinium-enhanced lesion in the right frontal lobe before first surgery. b After surgery, chemoradiotherapy and adjuvant TMZ-based chemotherapy, the tumor got a complete response. c, d and g Eleven months after initial treatment completion, tumor recurrence was confirmed by MRI, which demonstrated widespread disseminated lesions in the frontal horn of right lateral ventricle, genu of corpus callosum and spine. e, f and h After 4 months of combined chemotherapy, the tumors were significantly decreased