Fig. 1

Overview of the theraputic effects. Seven of 30 patients received more than 4 cycles of chemotherapy, including 6 patients got partial response (black spot) and 1 being in treatment (green arrow). The median time interval of first response was 4 (range, 2.0–6.6) months. Three patients got progressed, but not died (red arrow). After progression, 8 patients received bevacizumab treatment (marked with asterisk)