Fig. 1

GQC-05 induces apoptosis and DNA damage in KG1a cells but not CMK or TF-1 cells. The AML cell lines KG-1a, CMK and TF-1 were treated with vehicle (DMSO), 100 nM, 300 nM, 600 nM, or 1000 nM GQC-05 for 24 h. a Treated cells were assayed for Caspase 3/7 activity, normalized to DMSO treated cells and shown as mean fold change +/− S.D. * P < 0.002,** P < 0.0002 for quadruplicate samples of three biological replicates. b Apoptosis analysis using flow cytometry for Annexin V binding and nuclear (Vybrant Ruby) staining on AML cells treated with vehicle (DMSO) or 1000 nM GQC-05