TY - JOUR AU - Montoya, Justin J. AU - Turnidge, Megan A. AU - Wai, Daniel H. AU - Patel, Apurvi R. AU - Lee, David W. AU - Gokhale, Vijay AU - Hurley, Laurence H. AU - Arceci, Robert J. AU - Wetmore, Cynthia AU - Azorsa, David O. PY - 2019 DA - 2019/12/27 TI - In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells JO - BMC Cancer SP - 1251 VL - 19 IS - 1 AB - Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that arise from genomic alterations in the expression of key growth regulatory genes causing cells to assume an undifferentiated state and continue to proliferate. Recent efforts have focused on developing therapies that target specific protein products of aberrantly expressed genes. However, many of the identified proteins are difficult to target and thought to be “undrugable” because of structural challenges, protein overexpression, or mutations that confer resistance to therapy. A novel technology that circumvents some of these issues is the use of small molecules that stabilize secondary DNA structures present in the promoters of many potential oncogenes and modulate their transcription. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-019-6464-9 DO - 10.1186/s12885-019-6464-9 ID - Montoya2019 ER -