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Fig. 1 | BMC Cancer

Fig. 1

From: Non-destructive, label free identification of cell cycle phase in cancer cells by multispectral microscopy of autofluorescence

Fig. 1

Confocal laser scanning images of phases of the cell cycle. HeLa nuclei, blue is DAPI green is PCNA. G1 phase is distinguished by solid distribution of PCNA through the nucleus, S phase is distinguished by PCNA speckling through the nucleus and a nuclear border depending on position within S-phase (mid-S displayed here) as well as increased total DNA intensity compared to G1, G2 is distinguished by solid distribution of PCNA and twice the total DNA intensity of G1, M phase is distinguished by the exclusion of PCNA from the nucleus into the cytoplasm

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BMC Cancer

ISSN: 1471-2407

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