Fig. 4

Clustering patients into subtypes based on high degree nodes in the causal regulator network. (A) A heatmap showing the expression profiles of the top-50 important genes for the clustering results. Above the heatmap, annotations about the clustering labels and SMGs which showed significant enrichment in one of the cluster were shown. On the right side of the heatmap, the first column represents the importance score of each gene, and the other columns stand for the relevancies between the genes and SMGs where a green grid means that expressions of the gene is with significant difference between the SMG mutated and wild type samples. (B) Pathway enrichment analysis results for the top-50 important genes