Does chemoradiotherapy benefit elderly patients with esophageal squamous cell cancer? A propensity-score matched analysis on multicenter data (3JECROG R-03A)

Table 1 Clinical characteristics of pre- and post-matched patients

Characteristics	Pre-PSM				Post-PSM
Characteristics	CRT	RT-alone	χ2	P	CRT	RT-alone	χ2	P
Gender (n)			0.141	0.708			4.607	0.042
Male	84	366			76	91
Female	49	230			41	26
Mean age (year)	73.3 ± 3.58	76.2 ± 4.39		< 0.001	73.8 ± 3.7	73.9 ± 3.8		0.875
ECOG (n)			29.776	< 0.001			6.838	0.078
0	15	208			15	23
1	46	156			42	38
2	66	203			57	46
3	6	29			3	10
Preexisting chronic comorbidities (n)
Hypertension
yes	33	207	4.845	0.032	32	28	0.359	0.654
no	100	389			85	89
Cardiovascular disease
yes	16	78	0.108	0.886	14	22	2.101	0.204
no	117	518			103	95
Pulmonary disease
yes	14	57	0.115	0.747	13	20	1.729	0.26
no	119	539			104	97
Diabetes
yes	12	69	0.718	0.449	11	13	0.186	0.83
no	121	527			106	104
Tumor location (n)			10.204	0.037			4.728	0.316
Cervical	10	19			9	4
Upper	40	137			30	39
Middle	51	288			46	47
Lower	32	150			32	26
EGJ	0	2			0	1
Mean primary tumor length (cm)	5.50 ± 2.30	5.38 ± 2.27		0.564	5.5 ± 2.1	5.7 ± 2.4		0.426
Mean primary tumor volume (cm3)	50.82 ± 34.6	44.91 ± 33.14		0.255	50.2 ± 35.4	52.8 ± 32.4		0.56
Clinical T stage (n)			8.959	0.03			3.411	0.333
T1	0	10			0	3
T2	14	113			13	10
T3	56	245			53	52
T4	63	228			51	52
Clinical N stage (n)			0.14	0.769			0.018	1
N0	51	239			46	45
N1	82	357			71	72
Clinical M stage (n)			13.287	0.001			0.186	0.83
M0	114	564			106	104
M1	19	32			11	13
Primary T GTV Dose (cGy)	6120 ± 253	6067 ± 334		0.084	6105 ± 249	6052 ± 389		0.212

Cardiovascular disease: coronary artery disease [CAD] and atrial fibrillation [AF]
Pulmonary disease: chronic obstructive pulmonary disease [COPD] and asthma
EGJ Esophagogastric junction
PSM Propensity score matching