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Fig. 7 | BMC Cancer

Fig. 7

From: TOPK promotes metastasis of esophageal squamous cell carcinoma by activating the Src/GSK3β/STAT3 signaling pathway via γ-catenin

Fig. 7

HI-TOPK-032 suppresses lung metastasis in the KYSE510 cell xenograft model. a) Representative images for lung metastasis in the vehicle and HI-TOPK-032 treatment group are shown. b) Compared to the vehicle-treated group, the HI-TOPK-032-treated group exhibited significant suppression of KYSE510 cell lung metastasis. The asterisks (***) indicate a significant (p < 0.001) decrease in green fluorescent protein (GFP) radiant efficiency compared to control. c) HI-TOPK-032 had no effect on the bodyweight of mice. d) Western blotting analysis was used to determine the levels of γ-catenin and the phosphorylation levels of TOPK, Src, GSK3β, and ERK in the lung HI-TOPK-032-treated and vehicle-treated groups

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BMC Cancer

ISSN: 1471-2407

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